Ofstad J, Horvei G, Kvam F I, Mørkrid L, Sekse I, Svarstad E, Iversen B M
Medical Department A, University of Bergen, Norway.
Kidney Int Suppl. 1992 May;36:S8-14.
A descriptive survey of renal hemodynamics in the major experimental models of progressive renal disorders (primary loss of renal tissue, primary glomerular injury and primary hypertension) is given. Although the pathogenesis in the different models differs in several respects, increases in glomerular capillary pressure and renal growth factors are important for the development of progressive renal disorders. In primary glomerular disorders, interstitial immune reactions seem to be critical. In glomerular nephritis with increased capillary wall thickness, the increase in glomerular capillary pressure may be of less importance than in other models. A third important factor for progression of renal disorders is a gradual breakdown of autoregulation of renal blood flow and glomerular filtration rate exposing the glomerulus to the variations in systemic blood pressure.
本文对进行性肾脏疾病的主要实验模型（肾组织原发性丢失、原发性肾小球损伤和原发性高血压）中的肾脏血流动力学进行了描述性调查。尽管不同模型中的发病机制在几个方面有所不同，但肾小球毛细血管压力升高和肾脏生长因子对进行性肾脏疾病的发展很重要。在原发性肾小球疾病中，间质免疫反应似乎至关重要。在毛细血管壁厚度增加的肾小球肾炎中，肾小球毛细血管压力升高可能不如其他模型重要。肾脏疾病进展的第三个重要因素是肾血流量和肾小球滤过率的自动调节逐渐失效，使肾小球暴露于全身血压的变化中。
