Esmaili Javad, Safaee Seyyed Reza, Sharifian Ramezanali, Shoeybi Shahin, Gholamrezanezhad Ali
Nuclear Medicine Research Center, Shariati hospital, Tehran University of Medical Sciences, Northern Kargar St, 14114 Tehran, Iran.
Hell J Nucl Med. 2005 May-Aug;8(2):125-8.
To assess the diagnostic role of bone marrow scintigraphy (BMS) for detecting bone marrow infiltration by malignant lymphomas, 47 patients, 14 with malignant Hodgkin's and 33 with non-Hodgkin's lymphoma underwent BMS with 99mTc-sulphur-colloid and also unilateral iliac crest bone marrow biopsy (BMB). BM involvement in BMB was observed in 11 of the 47 patients. Four of these patients also had BMS lesions. Eight patients had BMS lesions not detected by BMB. There was poor agreement between the two modalities (kappa=0.137). Considering BMB as the gold standard, sensitivity, specificity, positive predictive value, negative predictive value and accuracy of BMS were 36%, 77%, 33%, 80%, and 68% respectively. In conclusion, BMS has a high negative predictive value and may be used as a complementary screening test for lymphoma to assess the extent of BM involvement, especially if magnetic resonance imaging-guided biopsy or positron emission tomography studies are not available, as is the case in developing countries.
为评估骨髓闪烁显像（BMS）在检测恶性淋巴瘤骨髓浸润方面的诊断作用，对47例患者进行了研究，其中14例为恶性霍奇金淋巴瘤，33例为非霍奇金淋巴瘤，这些患者均接受了99mTc-硫胶体骨髓闪烁显像检查以及单侧髂嵴骨髓活检（BMB）。47例患者中，11例在骨髓活检中观察到骨髓受累。其中4例患者同时存在骨髓闪烁显像病变。8例患者有骨髓闪烁显像病变，但骨髓活检未检测到。两种检查方法之间的一致性较差（kappa=0.137）。以骨髓活检作为金标准，骨髓闪烁显像的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为36%、77%、33%、80%和68%。总之，骨髓闪烁显像具有较高的阴性预测值，可作为淋巴瘤的补充筛查检查，以评估骨髓受累程度，特别是在发展中国家无法进行磁共振成像引导活检或正电子发射断层扫描研究的情况下。
