Med Tekh. 2005 Jul-Aug(4):54-6.
Pathophysiological mechanisms of intensive infusion therapy (IT) should be understood to provide effective practical use of this method for treating patients in critical states. Adequate IT should take into account the decrease in the efficiency of compensation mechanism and absence of reserve capacity of basic functional systems of human body. This allows the results of treatment of heavy patients to be improved, The goal of this work was to demonstrate that IT can be used not only as a therapeutic procedure but also as a diagnostic test intended to determine specific individual features of the compensatory adaptive reactions of the cardiovascular system (CVS) of patient. The tactics of IT can be adapted and optimized using the results of the CVS reaction to the liquid volume load test. The role of monitoring of hemodynamic parameters in IT was analyzed. Evaluation of patent reserves allows the following parameters of infusion to be varied: flow rate, volume, temperature, pH, and osmolarity of infusion solutions; succession and time of their infusion. Circadian rhythms of human CVS should also be taken into account. The following hemodynamic parameters should be monitored during IT: cardiac output, general peripheral resistance of blood vessels, and aqueous sectors. This monitoring can be used in mathematical simulation of changes in the parameters of central hemodynamics and determination of prognostic criteria.
应了解强化输注疗法（IT）的病理生理机制，以便有效地将该方法实际应用于治疗危重症患者。适当的IT应考虑到人体基本功能系统补偿机制效率的降低和储备能力的缺乏。这有助于提高重症患者的治疗效果。这项工作的目的是证明IT不仅可以作为一种治疗手段，还可以作为一种诊断测试，用于确定患者心血管系统（CVS）代偿性适应性反应的特定个体特征。可以根据CVS对液体容量负荷试验的反应结果来调整和优化IT策略。分析了血流动力学参数监测在IT中的作用。评估患者储备能力可改变以下输注参数：输注溶液的流速、体积、温度、pH值和渗透压；输注的顺序和时间。还应考虑人体CVS的昼夜节律。在IT期间应监测以下血流动力学参数：心输出量、全身外周血管阻力和血容量。这种监测可用于中央血流动力学参数变化的数学模拟和预后标准的确定。
