利用炔丙基酯原位生成金属卡宾进行铂催化的五元环化反应。
Pt-catalyzed pentannulations from in situ generated metallo-carbenoids utilizing propargylic esters.
作者信息
Bhanu Prasad B A, Yoshimoto Francis K, Sarpong Richmond
机构信息
Department of Chemistry, University of California, Berkeley, California 94720, USA.
出版信息
J Am Chem Soc. 2005 Sep 14;127(36):12468-9. doi: 10.1021/ja053192c.
Abstract
A highly selective and efficient Pt-catalyzed pentannulation reaction beginning from propargylic esters is described. The key to this reaction is the use of a PtCl2(PPh3)2/PhIO catalyst combination that allows the in situ generation of Pt-carbenoid intermediates, which lead to good yields (61-84%) of the desired pentannulated compounds.
摘要
描述了一种从炔丙基酯开始的高度选择性和高效的铂催化五环化反应。该反应的关键是使用PtCl2(PPh3)2/PhIO催化剂组合，该组合可原位生成铂卡宾中间体，从而以良好的产率（61-84%）得到所需的五环化化合物。
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