Sauk Jenny, Kane Sunanda
Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Expert Opin Pharmacother. 2005 Sep;6(11):1833-9. doi: 10.1517/14656566.6.11.1833.
Inflammatory bowel disease includes two primary disorders, ulcerative colitis and Crohn's disease. These diseases mainly affect young adults, with a peak occurrence between 15 and 25 years of age. The causes of these diseases are largely unknown, with current treatments targeted against the heightened inflammatory response witnessed in the intestinal mucosa of both conditions. With the peak age ranges for pregnancy and inflammatory bowel disease overlapping, it is important to weigh the benefits of treating a mother during pregnancy against the potential risks to the fetus and the course of the pregnancy. This review examines the current safety data on medications used in women with inflammatory bowel disease during pregnancy.
炎症性肠病包括两种主要病症,即溃疡性结肠炎和克罗恩病。这些疾病主要影响年轻人,发病高峰在15至25岁之间。这些疾病的病因大多不明,目前的治疗针对的是这两种病症肠道黏膜中出现的增强的炎症反应。由于怀孕的高峰年龄范围与炎症性肠病的高峰年龄范围重叠,权衡孕期治疗母亲的益处与对胎儿和妊娠过程的潜在风险非常重要。本综述研究了孕期用于患有炎症性肠病女性的药物的当前安全性数据。