Telegdy G, Tiricz H, Adamik A
Institute of Pathophysiology, Neurohumoral Research Group of the Hungarian Academy of Sciences, University of Szeged, H-6701 Szeged, Hungary.
Brain Res Bull. 2005 Oct 15;67(3):242-7. doi: 10.1016/j.brainresbull.2005.07.008.
The action of urocortin on one-way passive avoidance learning was tested in mice. Urocortin was administered into the lateral brain ventricle and the latency of the passive avoidance response was measured 24 h later. For study of the roles of various neurotransmitters in mediating the action of urocortin on the consolidation of memory, the animals were pretreated with different receptor antagonists. Urocortin facilitated the acquisition, consolidation and also retrieval of the passive avoidance response. The following receptor antagonists blocked the action of urocortin on consolidation: haloperidol, atropine, phenoxybenzamine, bicuculline, the CRF antagonist CRF9-41 and methysergide. Propranolol attenuated, but did not fully block the action of urocortin, while naloxone and nitro-L-arginine were ineffective. The results obtained demonstrate that urocortin is able to improve learning and memory and also retrieval processes in a passive avoidance learning in mice. D2, muscarinic cholinergic, alfa-adrenergic, CRF, serotonergic (5HT 1-2), GABA B receptors are involved in the consolidation of the passive avoidance response.
在小鼠中测试了尿皮质素对单向被动回避学习的作用。将尿皮质素注入侧脑室，24小时后测量被动回避反应的潜伏期。为了研究各种神经递质在介导尿皮质素对记忆巩固作用中的作用，对动物预先使用不同的受体拮抗剂进行处理。尿皮质素促进了被动回避反应的获得、巩固以及提取。以下受体拮抗剂阻断了尿皮质素对巩固的作用：氟哌啶醇、阿托品、酚苄明、荷包牡丹碱、促肾上腺皮质激素释放因子（CRF）拮抗剂CRF9 - 41和麦角新碱。普萘洛尔减弱了尿皮质素的作用，但未完全阻断，而纳洛酮和硝基 - L - 精氨酸则无效。所得结果表明，尿皮质素能够改善小鼠被动回避学习中的学习、记忆以及提取过程。D2、毒蕈碱型胆碱能、α - 肾上腺素能、CRF、5 - 羟色胺能（5HT 1 - 2）、GABA B受体参与了被动回避反应的巩固。
