Maxwell Patrick H
Renal Section, Hammersmith Campus, Imperial College London, Du Cane Road, London W12 0NN, UK.
Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):523-30. doi: 10.1016/j.semcdb.2005.03.001. Epub 2005 Apr 22.
The transcription factor hypoxia-inducible factor-1 (HIF) is commonly activated in cancer. This has major effects on gene expression, and is important in tumor angiogenesis. Besides being activated by low oxygen, genetic events in cancer contribute to activating HIF. Most striking is that loss of function of the VHL tumour suppressor protein results in constitutive activation of the HIF pathway. An important aim is to define the contribution of HIF activation to the evolution of different cancers, and its potential as a therapeutic target.
转录因子缺氧诱导因子-1（HIF）在癌症中通常被激活。这对基因表达有重大影响，并且在肿瘤血管生成中起重要作用。除了被低氧激活外，癌症中的遗传事件也有助于激活HIF。最显著的是，VHL肿瘤抑制蛋白功能丧失导致HIF途径的组成性激活。一个重要目标是确定HIF激活对不同癌症演变的作用，以及其作为治疗靶点的潜力。
