评估人类胚胎生殖细胞：作为多能干细胞的一致性与矛盾性
Evaluating human embryonic germ cells: concord and conflict as pluripotent stem cells.
作者信息
Turnpenny Lee, Spalluto Cosma M, Perrett Rebecca M, O'Shea Marie, Hanley Karen Piper, Cameron Iain T, Wilson David I, Hanley Neil A
机构信息
Early Human Development and Stem Cells Group, University of Southampton, Duthie Building (M.P. 808), Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom.
出版信息
Stem Cells. 2006 Feb;24(2):212-20. doi: 10.1634/stemcells.2005-0255. Epub 2005 Sep 6.
The realization of cell replacement therapy derived from human pluripotent stem cells requires full knowledge of the starting cell types as well as their differentiated progeny. Alongside embryonic stem cells, embryonic germ cells (EGCs) are an alternative source of pluripotent stem cell. Since 1998, four groups have described the derivation of human EGCs. This review analyzes the progress on derivation, culture, and differentiation, drawing comparison with other pluripotent stem cell populations.
源自人类多能干细胞的细胞替代疗法的实现需要全面了解起始细胞类型及其分化后代。除了胚胎干细胞，胚胎生殖细胞（EGC）是多能干细胞的另一种来源。自1998年以来，已有四个研究小组描述了人类EGC的分离。本综述分析了人类EGC在分离、培养和分化方面的进展，并与其他多能干细胞群体进行了比较。
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