Prochontschukov A A, Balaschov A N, Nowikov L L, Grudjanov A I
Zahn Mund Kieferheilkd Zentralbl. 1979;67(7):680-8.
Factorial planning of the program of testing provided significant evidence that, under the influence of a periodontally pathogenetic diet administered to animals, the enteral supply of fluoride tends to normalize the incorporation of Ca45 and P32 into the mineral fraction and further disturb the incorporation of P32 and lysine-1 C14 into the protein fraction of the bone tissue of the femur and jaw, respectively. Calcium electrophoresis provides for the normalization of the corresponding value of protein metabolism (incorporation of P32 and lysine-1 C14 into the organic fraction) in calcified tissues. Combined use of two therapeutic factors produces most favorable effects upon both the mineral and protein metabolism. This also reduces the negative effect exerted by the use of fluorine alone.
测试程序的析因设计提供了重要证据，即在给动物喂食牙周病致病饮食的影响下，肠道补充氟化物倾向于使Ca45和P32掺入矿物质部分正常化，并分别进一步干扰P32和赖氨酸-1 C14掺入股骨和颌骨骨组织的蛋白质部分。钙电泳可使钙化组织中蛋白质代谢的相应值（P32和赖氨酸-1 C14掺入有机部分）正常化。两种治疗因素的联合使用对矿物质和蛋白质代谢均产生最有利的影响。这也减少了单独使用氟所产生的负面影响。
