Barud Wojciech, Makaruk Bogusław, Myśliński Wojciech, Palusiński Robert, Hanzlik Janusz
Department of Internal Medicine, Skubiszewski Medical University of Lublin.
Ann Univ Mariae Curie Sklodowska Med. 2004;59(1):232-6.
Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity and mortality. The aim of the study was to find which factors influence left ventricular mass (LVM) and whether relationships exist between sex hormones: testosterone (T), estradiol (E2), sex hormone binding globulin (SHBG) and insulin resistance (HOMA-IR) and LVM. The study group consisted of 107 males at the age of over 50 years (mean 60.1 +/- 7.0). Positive significant correlations between LVM or left ventricle mass index (LVMI) and hypertension (0.23; p = 0.015 and 0.23; p = 0.019 respectively) as well as between LVM and body weight (0.38; p < 0.001) were observed. LVM and LVMI were higher in hypertensive than in normotensive men (279.9 +/- 82.2 vs. 243.4 +/- 70.3 g, p = 0.015 and 144.6 +/- 41.5 vs. 127.4 +/- 33.1 g/m2, p = 0.019 respectively). Multiple regression analysis showed LVM to be independently associated with hypertension and body weight. For LVMI such correlation was found only with hypertension. No relationships were observed between LVM/LVMI and insulin/insulin resistance.
左心室肥厚（LVH）是心血管疾病发病和死亡的独立危险因素。本研究的目的是找出哪些因素影响左心室质量（LVM），以及性激素：睾酮（T）、雌二醇（E2）、性激素结合球蛋白（SHBG）和胰岛素抵抗（HOMA-IR）与LVM之间是否存在关联。研究组由107名年龄超过50岁的男性组成（平均年龄60.1±7.0岁）。观察到LVM或左心室质量指数（LVMI）与高血压之间存在显著正相关（分别为0.23；p = 0.015和0.23；p = 0.019），以及LVM与体重之间存在显著正相关（0.38；p < 0.001）。高血压男性的LVM和LVMI高于血压正常的男性（分别为279.9±82.2 vs. 243.4±70.3 g，p = 0.015和144.6±41.5 vs. 127.4±33.1 g/m²，p = 0.019）。多元回归分析显示LVM与高血压和体重独立相关。对于LVMI，仅发现与高血压存在这种相关性。未观察到LVM/LVMI与胰岛素/胰岛素抵抗之间存在关联。
