Fukuda Ryuki, Kawada Hiroshi, Ogawa Yoshiaki, Yanagi Hidetaka, Kojima Seiichiro, Urano Tetsuya, Chie Ito, Onizuka Makoto, Fukagawa Satomi, Shimada Masako, Suzuki Rikio, Takagi Atsushi, Hotta Tomomitsu
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Tokai J Exp Clin Med. 2005 Jul;30(2):133-6.
Lung involvement is rare in Waldenström macroglobulinemia (WM). We encountered a male patient with WM who complained of breathlessness. Chest X-ray revealed diffuse infiltrative shadow throughout the both lungs. Transbronchial biopsy showed infiltration of atypical plasmacytoid lymphocytes and non-caseating granuloma. We treated the patients with fludarabine phosphate, and both his symptom and X-ray findings were then improved. To our knowledge, this is the first case showing non-caseating granuloma with lung involvement of WM. We discuss a mechanism of non-caseating granuloma formation in this case.
