关于（-）-肯多霉素全合成的研究工作。
Efforts toward the total synthesis of (-)-kendomycin.
作者信息
Williams David R, Shamim Khalida
机构信息
Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, Indiana 47405, USA.
出版信息
Org Lett. 2005 Sep 15;7(19):4161-4. doi: 10.1021/ol051512r.
PMID:16146377
Abstract
[structure: see text] The synthesis of an advanced component leading to (-)-kendomycin is described. The synthetic scheme features the application of asymmetric conjugate addition methodology for the early generation of the C13-C14 (E)-trisubstituted olefin, providing an efficient assembly of the ansa chain. Condensation reactions probe two strategies for attachment of the aromatic system.
摘要
[结构：见正文] 描述了导致（-）-肯多霉素的一种高级组分的合成。该合成方案的特点是应用不对称共轭加成方法来早期生成C13-C14（E）-三取代烯烃，从而高效组装桥链。缩合反应探索了连接芳香体系的两种策略。
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