盐酸植物鞘氨醇在不同实验性大鼠溃疡模型中的抗溃疡作用

Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models.

作者信息

Baek Seung Woo, Kim Nam Ki, Jin Hwan-Jun, Koh Chang-Woong, Kim Chul Kyung, Kwon O-Hyep, Kim Jun-Sung, Cho Myung-Haing, Park Chan-Koo

机构信息

Laboratory of Biochemical Engineering, Department of Chemical Engineering, Sung kyun kwan University, Suwon, Korea.

出版信息

Arzneimittelforschung. 2005;55(8):461-5. doi: 10.1055/s-0031-1296889.

DOI:10.1055/s-0031-1296889

PMID:16149714

Abstract

The gastroprotective activity of phytosphingosine hydrochloride (PS-HCl, CAS 554-62-1) was assessed in four different rat models of experimentally induced gastric ulcer. Various doses (2.5-10 mg/kg) of PS-HCI were orally administered to rats 30 min before the treatment with HCl/ethanol, indometacin, cysteamine, or to rats with ligated pylorus. Oral administration of PS-HCl (2.5-10 mg/kg) to rats prevented the acute ulcer formation in 4 different types of ulcer in a dose-dependent manner as follows: (1) HCl/ethanol-induced gastric mucosal membrane lesions (20.1-47.8% inhibition), (2) indometacin-induced gastric mucosal membrane lesions (4.6-31.9% inhibition), (3) duodenal ulcer induced by cysteamine (10-20% inhibition), (4) gastric secretion and ulceration following pylorus ligation (33.3-61.9% inhibition). These results indicate that PS-HCI may be useful for the prevention of gastric ulcer.

摘要

在四种不同的实验性诱导胃溃疡大鼠模型中评估了盐酸植物鞘氨醇（PS-HCl，CAS 554-62-1）的胃保护活性。在给予盐酸/乙醇、吲哚美辛、半胱胺治疗前30分钟，将不同剂量（2.5-10mg/kg）的PS-HCl口服给予大鼠，或将其给予幽门结扎的大鼠。给大鼠口服PS-HCl（2.5-10mg/kg）以剂量依赖性方式预防了4种不同类型溃疡中的急性溃疡形成，具体如下：（1）盐酸/乙醇诱导的胃黏膜损伤（抑制率20.1-47.8%），（2）吲哚美辛诱导胃黏膜损伤（抑制率4.6-31.9%），（3）半胱胺诱导的十二指肠溃疡（抑制率10-20%），（4）幽门结扎后的胃液分泌和溃疡形成（抑制率33.3-61.9%）。这些结果表明，PS-HCl可能对预防胃溃疡有用。