Asad M, Shewade D G, Koumaravelou K, Abraham B K, Vasu S, Ramaswamy S
Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry, India.
Life Sci. 2001 Nov 21;70(1):17-24. doi: 10.1016/s0024-3205(01)01376-5.
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied. The acute gastric ulcer models used were pylorus ligation, indomethacin, ethanol and histamine induced acute gastric ulcers. Chronic gastric ulcers were induced using acetic acid and duodenal ulcers by cysteamine hydrochloride. Oxytocin showed significant antisecretory and antiulcer activity in pylorus ligated rats. Similarly oxytocin reduced the ulcer index in histamine induced gastric ulcers in guinea pigs and cysteamine induced duodenal ulcers in rats. The antiulcer and antisecretory effect was comparable to that of ranitidine (50mg/kg, i.p) though less in intensity. However, it did not show any gastric cytoprotective effect in ethanol and indomethacin induced ulcer models but ranitidine showed protection (p<0.05) in later model. Oxytocin enhanced gastric ulcer healing in acetic acid induced chronic gastric ulcer model. The reversal of oxytocin effect by atosiban, an oxytocin receptor antagonist indicates a role for oxytocin receptors. The antiulcer activity of oxytocin can be attributed to its antisecretory effect.
研究了催产素（1毫克/千克，皮下注射）对胃酸分泌以及不同实验性诱导的胃溃疡和十二指肠溃疡的影响。所使用的急性胃溃疡模型有幽门结扎、吲哚美辛、乙醇和组胺诱导的急性胃溃疡。慢性胃溃疡通过乙酸诱导，十二指肠溃疡通过盐酸半胱胺诱导。催产素在幽门结扎的大鼠中显示出显著的抗分泌和抗溃疡活性。同样，催产素降低了组胺诱导的豚鼠胃溃疡和半胱胺诱导的大鼠十二指肠溃疡的溃疡指数。其抗溃疡和抗分泌作用与雷尼替丁（50毫克/千克，腹腔注射）相当，尽管强度较小。然而，在乙醇和吲哚美辛诱导的溃疡模型中，它未显示出任何胃细胞保护作用，但雷尼替丁在后者模型中显示出保护作用（p<0.05）。催产素促进了乙酸诱导的慢性胃溃疡模型中的溃疡愈合。催产素受体拮抗剂阿托西班对催产素作用的逆转表明了催产素受体的作用。催产素的抗溃疡活性可归因于其抗分泌作用。
