通过乙炔胺与二氧化碳电化学促进形成C-N键。5-亚甲基-1,3-恶唑烷-2-酮的合成。
Electrochemically promoted C-N bond formation from acetylenic amines and CO2. Synthesis of 5-methylene-1,3-oxazolidin-2-ones.
作者信息
Feroci Marta, Orsini Monica, Sotgiu Giovanni, Rossi Leucio, Inesi Achille
机构信息
Dip. Ingegneria Chimica, Materiali, Materie Prime e Metallurgia, Università La Sapienza, via Castro Laurenziano, 7, I-00161 Roma, Italy.
出版信息
J Org Chem. 2005 Sep 16;70(19):7795-8. doi: 10.1021/jo0511804.
[reaction: see text] An efficient electrochemical synthesis of 5-methylene-1,3-oxazolidin-2-ones (2a-h) from acetylenic amines (1a-h) and carbon dioxide has been achieved by direct electrolysis of solution of MeCN and Et4NPF6 containing the amine, with subsequent CO2 bubbling and heating. The yields vary from good to excellent, the conditions are mild, and the use of toxic and harmful chemicals and catalysts is avoided.
[反应：见正文] 通过直接电解含有炔胺（1a - h）的乙腈和四乙基铵六氟磷酸盐溶液，随后通入二氧化碳并加热，实现了从炔胺（1a - h）和二氧化碳高效电化学合成5 - 亚甲基 - 1,3 - 恶唑烷 - 2 - 酮（2a - h）。产率从良好到优异不等，条件温和，且避免了使用有毒有害化学品和催化剂。
Zotero 插件