Wolf B
Sektion Biowissenschaften, Universität Leipzig-Lehrstuhl Pharmazeutische Technologie.
Pharmazie. 1992 Mar;47(3):204-7.
Examination of in vitro liberation of prazosin hydrochloride and benzocaine from formulations of matrix type with bead cellulose and bead cellulose derivatives shows deviations from first order kinetics owing to competition of several processes: dissociation of ionic bonds or cleavage of covalent bonds between drugs and bead cellulose, pore diffusion, dissolution of the drugs and swelling of cellulose matrix. Suitable combinations of different bonded portions of the drug on bead celluloses let these complexes seem to be successful in the use for controlled and retarded liberation of drugs.
对含珠状纤维素和珠状纤维素衍生物的基质型制剂中盐酸哌唑嗪和苯佐卡因的体外释放进行研究，结果表明，由于多种过程的竞争，其释放偏离一级动力学：药物与珠状纤维素之间离子键的解离或共价键的断裂、孔扩散、药物溶解以及纤维素基质的溶胀。药物在珠状纤维素上不同结合部分的合适组合，使得这些复合物在用于药物的控释和缓释方面似乎是成功的。
