Green Nancy S, Damus Karla, Simpson Joe Leigh, Iams Jay, Reece E Albert, Hobel Calvin J, Merkatz Irwin R, Greene Michael F, Schwarz Richard H
March of Dimes, White Plains, NY, USA.
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):626-35. doi: 10.1016/j.ajog.2005.02.106.
Preterm birth (PTB) is a common, serious, and costly health problem affecting nearly 1 in 8 births in the United States. Burdens from PTB are especially severe for the very preterm infant (<32 weeks' gestation), comprising 2% of all US births. Successful prevention needs to include newly focused and adequately funded research, incorporating new technologies and recognition that genetic, environmental, social, and behavioral factors interact in complex pathogeneses and multiple pathways leading to PTB. The March of Dimes Scientific Advisory Committee created this prioritized research agenda, which is aimed at garnering serious attention and expanding resources to make major inroads into the prevention of PTB, targeting six major, overlapping categories: epidemiology, genetics, disparities, inflammation, biologic stress, and clinical trials. Analogous to other common, complex disorders, progress in prevention will require incorporating multipronged risk reduction strategies that are based on sound scientific discovery, as well as on effective translation into clinical care.
早产是一个常见、严重且代价高昂的健康问题，在美国，每8例分娩中就有近1例受其影响。早产对极早产儿（孕周<32周）的负担尤为严重，这类婴儿占美国所有出生人口的2%。成功的预防需要包括新的重点研究和充足的资金投入，整合新技术，并认识到遗传、环境、社会和行为因素在导致早产的复杂发病机制和多种途径中相互作用。美国疾病控制与预防中心科学咨询委员会制定了这一优先研究议程，旨在引起高度重视并扩大资源，以便在预防早产方面取得重大进展，目标涉及六个主要的重叠类别：流行病学、遗传学、差异、炎症、生物应激和临床试验。与其他常见的复杂疾病类似，预防工作的进展需要纳入基于可靠科学发现以及有效转化为临床护理的多管齐下的风险降低策略。
