White B C, Tintinalli J E
JACEP. 1977 May;6(5):187-90. doi: 10.1016/s0361-1124(77)80493-0.
To study whether sodium bicarbonate given in cardiopulmonary resuscitation may produce life-threatening hyperosmolality or hypernatremia, arterial blood was analysed for blood gas, alcohol, blood urea nitrogen, electrolyte and osmolality. The blood was drawn after resuscitation in successful cases, and while effective massage and ventilation were being applied in unsuccessful resuscitations. Seven of the 17 resuscitations were successful. Serum sodium concentrations ranged from 135 to 154 with one exception and did not correlate with the amount of sodium bicarbonate administered. Arterial pH ranged from 6.38 to 7.71; only one patient had metabolic alkalosis. Serum osmolality ranged from 301 to 407. The data suggests a net increase in osmolality of 6 mOsm/50 mEq of sodium bicarbonate.
为研究在心肺复苏过程中给予碳酸氢钠是否会导致危及生命的高渗性或高钠血症，对动脉血进行了血气、酒精、血尿素氮、电解质和渗透压分析。在成功复苏的病例中，复苏后采集血液；在复苏失败的病例中，在进行有效按摩和通气时采集血液。17次复苏中有7次成功。血清钠浓度范围为135至154（有1例例外），且与碳酸氢钠给药量无关。动脉pH值范围为6.38至7.71；只有1例患者出现代谢性碱中毒。血清渗透压范围为301至407。数据表明，每50 mEq碳酸氢钠的渗透压净增加6 mOsm。
