与兔流行性肠病相关的感染因子：分离及重现该综合征的尝试。
Infectious agents associated with epizootic rabbit enteropathy: isolation and attempts to reproduce the syndrome.
作者信息
Marlier D, Dewrée R, Lassence C, Licois D, Mainil J, Coudert P, Meulemans L, Ducatelle R, Vindevogel H
机构信息
University of Liège, Faculty of Veterinary Medicine, Department of Infectious and Parasitic Diseases, Birds and Rabbits Medicine, Sart Tilman, Bât B42, Liège, Belgium.
出版信息
Vet J. 2006 Nov;172(3):493-500. doi: 10.1016/j.tvjl.2005.07.011. Epub 2005 Sep 9.
Epizootic rabbit enteropathy (ERE), a highly lethal (30-80% mortality) disease of broiler rabbits aged 6-14 weeks, first appeared in 1997 in French intensive enclosed rabbitries and is of unknown aetiology. Bacteriological, virological and parasitical examination of the intestinal contents of rabbits that had died either in spontaneous field cases or after experimental reproduction of ERE, were undertaken in an attempt to identify infectious agents that may play a role in the disease. Two bacterial strains, Clostridium perfringens and non-enteropathogenic Escherichia coli were repeatedly isolated at high faecal counts from naturally infected animals. In field cases, a correlation between typical gross lesions of epizootic enteropathy and the presence of the alpha toxin of Cl. perfringens was observed (P<0.0001; Chi-squared test). Although attempts to reproduce the disease by inoculation with different pools of cultivable bacterial strains failed, the disease was successfully reproduced by inoculation with one French and two Belgian samples of caecal contents.
兔流行性肠炎（ERE）是一种发生于6至14周龄肉兔的高致死性疾病（死亡率为30%-80%），1997年首次出现在法国的集约化封闭式兔场，病因不明。对在自然发病或ERE实验复制后死亡的兔子的肠道内容物进行了细菌学、病毒学和寄生虫学检查，试图确定可能与该病有关的感染因子。从自然感染动物的粪便中多次分离出两种细菌菌株，产气荚膜梭菌和非致病性大肠杆菌，且粪便计数较高。在野外病例中，观察到兔流行性肠炎的典型肉眼病变与产气荚膜梭菌α毒素的存在之间存在相关性（P<0.0001；卡方检验）。尽管用不同的可培养细菌菌株接种来复制该病的尝试失败了，但用一份法国和两份比利时盲肠内容物样本接种成功复制了该病。
Zotero 插件