Lossos Izidore S
University of Miami, Sylvester Comprehensive Cancer Center, Department of Hematology and Oncology, 1475 NW 12th Ave (D8-4), Miami, FL 33136, USA.
J Clin Oncol. 2005 Sep 10;23(26):6351-7. doi: 10.1200/JCO.2005.05.012.
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathologic entity accounting for 30% of non-Hodgkin's lymphomas. The pathogenesis of DLBCL is complex and heterogeneous. Recent studies using analysis of global gene expression with DNA microarrays and the classical molecular approaches demonstrate presence of several DLBCL subtypes characterized by different cells of origin, cytogenetic and molecular aberrations, and distinct pathogenesis. This review summarizes the progress in understanding of DLBCL biology and presents a state-of-the-art overview of DLBCL molecular pathogenesis.
弥漫性大B细胞淋巴瘤（DLBCL）是一种异质性的临床病理实体，占非霍奇金淋巴瘤的30%。DLBCL的发病机制复杂且具有异质性。最近使用DNA微阵列进行全基因组表达分析以及经典分子方法的研究表明，存在几种DLBCL亚型，其特征为不同的细胞起源、细胞遗传学和分子异常以及不同的发病机制。本综述总结了对DLBCL生物学理解的进展，并对DLBCL分子发病机制进行了最新概述。
