工作压力维度与炎症和感染生物标志物之间的关联。
Associations between dimensions of job stress and biomarkers of inflammation and infection.
作者信息
Clays Els, De Bacquer Dirk, Delanghe Joris, Kittel France, Van Renterghem Lieve, De Backer Guy
机构信息
Department of Public Health, Ghent University, University Hospital, Belgium.
出版信息
J Occup Environ Med. 2005 Sep;47(9):878-83. doi: 10.1097/01.jom.0000171056.22917.ad.
OBJECTIVE
The objective of this study was to examine associations between dimensions of job stress and indicators of chronic inflammation and infection.
METHODS
Within a subsample from the BELSTRESS study of 892 male subjects free of cardiovascular disease, dimensions of job stress from the job demand-control-support model were related to biomarkers of inflammation (plasma fibrinogen concentrations, high-sensitivity C-reactive protein, and serum amyloid A) and infection (titers against Chlamydia pneumoniae, cytomegalovirus, and Helicobacter pylori).
RESULTS
A negative association was found between job control and plasma fibrinogen concentration, independent from age, education, occupation, body mass index, smoking, alcohol consumption, and use of lipid-lowering and antihypertensive medication. Higher social support at work was independently related to an increased risk of positive titers against cytomegalovirus.
CONCLUSIONS
Results confirm previous findings regarding elevated plasma fibrinogen and low job control.
目的
本研究的目的是检验工作压力维度与慢性炎症和感染指标之间的关联。
方法
在BELSTRESS研究的892名无心血管疾病的男性受试者子样本中，工作需求 - 控制 - 支持模型中的工作压力维度与炎症生物标志物（血浆纤维蛋白原浓度、高敏C反应蛋白和血清淀粉样蛋白A）及感染（抗肺炎衣原体、巨细胞病毒和幽门螺杆菌的滴度）相关。
结果
发现工作控制与血浆纤维蛋白原浓度之间存在负相关，独立于年龄、教育程度、职业、体重指数、吸烟、饮酒以及使用降脂和降压药物。工作中较高的社会支持与抗巨细胞病毒滴度呈阳性的风险增加独立相关。
结论
结果证实了先前关于血浆纤维蛋白原升高和工作控制低的研究发现。
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