Nicot Christophe, Harrod Robert L, Ciminale Vincenzo, Franchini Genoveffa
Department of Microbiology, University of Kansas Medical Center, Molecular Genetics, and Immunology, 3025 Wahl Hall West, 3901 Rainbow Boulevard, Kansas City, KS 66160-7420, USA.
Oncogene. 2005 Sep 5;24(39):6026-34. doi: 10.1038/sj.onc.1208977.
The human T-cell leukemia/lymphoma virus (HTLV) genome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at its 3' end originally designated pX. To date, we know that this region encodes two essential transcriptional and post-transcriptional positive regulators of viral expression, the Tax and Rex proteins, respectively (reviewed elsewhere in this issue). Here, we will review current knowledge of the functions of three additional proteins encoded in the pX region, p12I, p13II, and p30II.
人类T细胞白血病/淋巴瘤病毒（HTLV）基因组，除了结构蛋白Gag和Env以及逆转录病毒酶之外，在其3'端还携带一个最初命名为pX的区域。迄今为止，我们知道该区域分别编码病毒表达的两种重要转录和转录后正调控因子，即Tax和Rex蛋白（本期其他地方有综述）。在这里，我们将综述pX区域编码的另外三种蛋白p12I、p13II和p30II功能的现有知识。
