Demoly P, Gomes E Rebelo
Allergy Department, Maladies Respiratoires and INSERM U454, IFR3, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France.
Eur Ann Allergy Clin Immunol. 2005 Jun;37(6):202-6.
Drug hypersensitivity reactions are the adverse effects of drugs taken at a dose which is tolerated by normal subjects, and which clinically resemble allergy. There is few true epidemiological data on drug hypersensitivity reactions. The available information requires a cautious interpretation as they are rarely proven. Both under diagnosis and over diagnosis must be taken into account. Drug hypersensitivity reactions represent one third of adverse drug reactions, can be life threatening and motivate changes on drug prescription. They concern more than 7% of the general population, therefore being an important public health problem. A few risk factors are already pinpointed. Future progress in genetics can help the identification of populations at risk for specific reactions. This review describes currently known data on incidence,prevalence, mor tality and risk factors of these reactions.
药物超敏反应是指在正常受试者可耐受剂量下服用药物时出现的不良反应，临床表现类似于过敏反应。关于药物超敏反应，几乎没有真实的流行病学数据。现有信息需要谨慎解读，因为它们很少得到证实。必须考虑诊断不足和诊断过度的情况。药物超敏反应占药物不良反应的三分之一，可能危及生命，并促使改变药物处方。它们涉及超过7%的普通人群，因此是一个重要的公共卫生问题。一些风险因素已经被确定。遗传学方面的未来进展有助于识别有特定反应风险的人群。本综述描述了目前已知的关于这些反应的发病率、患病率、死亡率和风险因素的数据。
