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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hambrook J L, Harrison J M, Howells D J, Schock C

Chemical Defence Establishment, Salisbury, Wiltshire, UK.

Xenobiotica. 1992 Jan;22(1):65-75. doi: 10.3109/00498259209053104.

A technique for the quantitative cutaneous application of sulphur mustard vapour is described. The maximum rate of uptake of the agent vapour by shaved rat skin in vivo was estimated as 7 micrograms/cm2 per min. 2. The major route of excretion was through the kidneys: greater than 70% of the radioactivity of all doses was excreted in 3 days after either i.v. or i.p. injections of 35S-labelled sulphur mustard, but less (50-70% depending on dose) was excreted in the same time following cutaneous application. 3. This urinary excretion of 35S had a half-life of 1.4 days, and the decreased proportion of the applied dose excreted following cutaneous application may be accounted for by retention of radioactivity in the skin. 4. The contribution of faecal excretion was greater following cutaneous application.

描述了一种定量皮肤应用硫芥气的技术。体内剃毛大鼠皮肤对该毒剂蒸气的最大摄取速率估计为每分钟7微克/平方厘米。2. 主要排泄途径是通过肾脏：静脉注射或腹腔注射35S标记的硫芥后，所有剂量的放射性超过70%在3天内排出，但皮肤应用后在相同时间内排出的较少（取决于剂量为50%-70%）。3. 35S的这种尿排泄半衰期为1.4天，皮肤应用后排泄的给药剂量比例降低可能是由于放射性在皮肤中的滞留。4. 皮肤应用后粪便排泄的贡献更大。

Hambrook J L, Harrison J M, Howells D J, Schock C

Chemical Defence Establishment, Salisbury, Wiltshire, UK.

Xenobiotica. 1992 Jan;22(1):65-75. doi: 10.3109/00498259209053104.

A technique for the quantitative cutaneous application of sulphur mustard vapour is described. The maximum rate of uptake of the agent vapour by shaved rat skin in vivo was estimated as 7 micrograms/cm2 per min. 2. The major route of excretion was through the kidneys: greater than 70% of the radioactivity of all doses was excreted in 3 days after either i.v. or i.p. injections of 35S-labelled sulphur mustard, but less (50-70% depending on dose) was excreted in the same time following cutaneous application. 3. This urinary excretion of 35S had a half-life of 1.4 days, and the decreased proportion of the applied dose excreted following cutaneous application may be accounted for by retention of radioactivity in the skin. 4. The contribution of faecal excretion was greater following cutaneous application.

描述了一种定量皮肤应用硫芥气的技术。体内剃毛大鼠皮肤对该毒剂蒸气的最大摄取速率估计为每分钟7微克/平方厘米。2. 主要排泄途径是通过肾脏：静脉注射或腹腔注射35S标记的硫芥后，所有剂量的放射性超过70%在3天内排出，但皮肤应用后在相同时间内排出的较少（取决于剂量为50%-70%）。3. 35S的这种尿排泄半衰期为1.4天，皮肤应用后排泄的给药剂量比例降低可能是由于放射性在皮肤中的滞留。4. 皮肤应用后粪便排泄的贡献更大。