患有和未患先兆子痫的正常体重、超重及肥胖孕妇体内瘦素、脂联素和抵抗素的水平。

The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia.

作者信息

Hendler Israel, Blackwell Sean C, Mehta Shobha H, Whitty Janice E, Russell Evelyne, Sorokin Yoram, Cotton David B

机构信息

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Hutzel Hospital-Wayne State University, Detroit, MI 48201, USA.

出版信息

Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):979-83. doi: 10.1016/j.ajog.2005.06.041.

DOI:10.1016/j.ajog.2005.06.041

PMID:16157097

Abstract

OBJECTIVE

The purpose of this study was to compare adipokines' levels between women with and without preeclampsia based on maternal body mass index (BMI).

STUDY DESIGN

This was a cross-sectional study among third-trimester pregnancies with preeclampsia (PIH) compared with normotensive controls. Serum levels of adiponectin, leptin, and resistin were measured before delivery by radioimmunoassay or enzyme-linked immunosorbent assay (ELISA).

RESULTS

The study included 22 normotensive and 77 PIH women. Leptin levels increased with maternal BMI. In patients with severe preeclampsia, overweight, and obese women had increased leptin levels (33.4 +/- 14.8 vs 23.0 +/- 10.8 ng/mL respectively, P = .02), and decreased adiponectin levels (8.4 +/- 5.3 vs 12.6 +/- 6.0 ng/mL, P = .03) compared with normal weight women. In women with BMI <25 kg/m2, adiponectin levels increased in patients with preeclampsia compared with controls (11.5 +/- 5.6 vs 9.6 +/- 4.6 and 7.0 +/- 3.2 ng/mL, respectively, P = .005). There was no association between resistin levels and preeclampsia or maternal BMI.

CONCLUSION

Women with severe preeclampsia and BMI > or = 25 kg/m2 have decreased adiponectin and increased leptin levels, while normal weight women with preeclampsia have increased adiponectin levels.

摘要

目的

本研究旨在根据孕妇体重指数（BMI）比较子痫前期患者与非子痫前期患者的脂肪因子水平。

研究设计

这是一项横断面研究，将孕晚期子痫前期（PIH）孕妇与血压正常的对照组进行比较。在分娩前通过放射免疫分析或酶联免疫吸附测定（ELISA）测量血清脂联素、瘦素和抵抗素水平。

结果

该研究纳入了22名血压正常的女性和77名PIH女性。瘦素水平随孕妇BMI升高而增加。在重度子痫前期患者中，超重和肥胖女性的瘦素水平升高（分别为33.4±14.8 vs 23.0±10.8 ng/mL，P = 0.02），与正常体重女性相比，脂联素水平降低（8.4±5.3 vs 12.6±6.0 ng/mL，P = 0.03）。在BMI<25 kg/m²的女性中，子痫前期患者的脂联素水平高于对照组（分别为11.5±5.6 vs 9.6±4.6和7.0±3.2 ng/mL，P = 0.005）。抵抗素水平与子痫前期或孕妇BMI之间无关联。