Hasegawa G, Ohta M, Ichida Y, Obayashi H, Shigeta M, Yamasaki M, Fukui M, Yoshikawa T, Nakamura N
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Hirokoji, Kawaramachi-dori, Kamikyo-ku, Japan.
Acta Diabetol. 2005 Jun;42(2):104-9. doi: 10.1007/s00592-005-0187-x.
The role of resistin in human biology remains uncertain. We measured serum resistin levels in Japanese patients with (n=111) and without (n=98) type 2 diabetes mellitus and investigated the significance of this hormone in the pathophysiology of diabetes. The levels of serum adiponectin and leptin were also measured. Resistin levels were increased significantly in patients with type 2 diabetes compared with non-diabetic subjects (24.7+/-2.6 vs. 15.0+/-1.2 ng/ml, p=0.0013). However, there was no correlation in either patient group between serum resistin levels and markers of insulin resistance, obesity or hyperlipidaemia. These results were in direct contrast to the data of leptin or adiponectin, both of which were closely related to these clinical markers of diabetes. Multivariate regression analysis on the combined data of the two groups demonstrated that the presence of diabetes and HDL cholesterol levels were significant predictors of serum resistin levels (diabetes: beta=0.159, p=0.035; HDL: beta=-0.172, p=0.039). No correlation was observed between C-reactive protein and resistin adjusted for BMI. Taken together, these findings demonstrate that serum resistin levels are increased in patients with type 2 diabetes, but this increase is not linked to markers of insulin resistance or adiposity. Further studies are necessary to elucidate the significance of serum resistin concentration in human pathophysiology.
抵抗素在人类生物学中的作用仍不明确。我们测定了111例2型糖尿病日本患者及98例非2型糖尿病日本患者的血清抵抗素水平，并研究了这种激素在糖尿病病理生理学中的意义。同时还测定了血清脂联素和瘦素水平。与非糖尿病受试者相比，2型糖尿病患者的抵抗素水平显著升高（24.7±2.6 vs. 15.0±1.2 ng/ml，p = 0.0013）。然而，在两组患者中，血清抵抗素水平与胰岛素抵抗、肥胖或高脂血症标志物之间均无相关性。这些结果与瘦素或脂联素的数据形成直接对比，后两者均与糖尿病的这些临床标志物密切相关。对两组合并数据进行多因素回归分析表明，糖尿病的存在和高密度脂蛋白胆固醇水平是血清抵抗素水平的显著预测因素（糖尿病：β = 0.159，p = 0.035；高密度脂蛋白：β = -0.172，p = 0.039）。校正体重指数后，未观察到C反应蛋白与抵抗素之间存在相关性。综上所述，这些发现表明2型糖尿病患者的血清抵抗素水平升高，但这种升高与胰岛素抵抗或肥胖标志物无关。需要进一步研究以阐明血清抵抗素浓度在人类病理生理学中的意义。
