Kawada Tomoyuki, Katsumata Masao, Suzuki Hiroko, Li Qing, Inagaki Hirofumi, Nakadai Ari, Shimizu Takako, Hirata Kimiko, Hirata Yukiyo
Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo 113-8602, Japan.
Percept Mot Skills. 2005 Jun;100(3 Pt 2):1121-6. doi: 10.2466/pms.100.3c.1121-1126.
More than 5,000 passengers on Tokyo subway trains were injured with toxic chemicals including the nerve gas "sarin" on March 20, 1995. The purpose of this study was to identify the effect of sarin exposure on insomnia in a cross-sectional study. A self-administered questionnaire concerning sleep-related items was distributed to victims of sarin exposure in October and November, 2003. Questionnaires were completed by 161 of the 163 participants (98.8%), who were selected from 1,500 subjects. Among them, the authors selected 75 women 30 to 69 years of age. Control participants were collected from inhabitants living in Maebachi City, Gunma Prefecture, Japan. For the younger exposed group (under 50 yr. of age), percentages of poor sleep, difficulty falling asleep, intermittent awakening, early morning awakening, a feeling of light overnight sleep, and insomnia were significantly higher than those for the control group. In contrast, the older exposed group (ages 50 to 69 years) had significantly higher prevalence of poor sleep, a feeling of light overnight sleep, and early morning awakening for the exposed group when compared with the control group. The high prevalence of insomnia and insomnia-related factors for victims especially under 50 years of age suggests a need for research on sleep quality after sarin exposure. Although posttraumatic stress disorder is assumed to be a psychological effect of exposure to a toxic substance, a cause-and-effect relationship has not been established.
1995年3月20日，东京地铁列车上有5000多名乘客因包括神经毒气“沙林”在内的有毒化学品而受伤。本研究的目的是在一项横断面研究中确定沙林暴露对失眠的影响。2003年10月和11月，向沙林暴露受害者发放了一份关于睡眠相关项目的自填式问卷。163名参与者中有161人（98.8%）完成了问卷，这些参与者是从1500名受试者中挑选出来的。其中，作者挑选了75名年龄在30至69岁之间的女性。对照参与者是从日本群马县前桥市的居民中收集的。对于较年轻的暴露组（50岁以下），睡眠质量差、入睡困难、间歇性觉醒、早醒、夜间睡眠浅和失眠的比例显著高于对照组。相比之下，与对照组相比，年龄较大的暴露组（50至69岁）睡眠质量差、夜间睡眠浅和早醒的患病率显著更高。尤其是50岁以下受害者失眠及失眠相关因素的高患病率表明需要对沙林暴露后的睡眠质量进行研究。尽管创伤后应激障碍被认为是接触有毒物质的心理影响，但因果关系尚未确立。
