• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

东京沙林毒气袭击事件十年后:受害者神经学随访情况综述

A decade after the Tokyo sarin attack: a review of neurological follow-up of the victims.

作者信息

Hoffman Azik, Eisenkraft Arik, Finkelstein Arseny, Schein Ophir, Rotman Eran, Dushnitsky Tsvika

机构信息

Chemical, Biological, Radiological and Nuclear Medicine Branch, Medical Corps, Israel Defense Forces, Tel Hashomer Military Base, Ramat Gan, Israel 02149.

出版信息

Mil Med. 2007 Jun;172(6):607-10. doi: 10.7205/milmed.172.6.607.

DOI:10.7205/milmed.172.6.607
PMID:17615841
Abstract

OBJECTIVE

On March 20, 1995, sarin gas was used in Tokyo by members of the Japanese "Uhm-Shinrikiu" cult, killing 12 and injuring >5,500 innocent people. Most of the casualties were mildly injured. This article reviews the neurological follow-up data for some of the victims over the past decade.

METHODS

We reviewed the published literature regarding neurological follow-up of the victims, dividing the data according to the time elapsed after the attack.

RESULTS

The digit span test, finger-tapping test, and computerized posturography were the only performance tests that showed statistically significant differences between the victims and the control groups in some of the surveys. The main sequela 7 years after the attack was post-traumatic stress disorder.

CONCLUSIONS

The results emphasize the need for a national preparedness program for such mass casualty events, led by national health systems. This should include long-term, neurological, follow-up monitoring with performance tests and a post-traumatic stress disorder screening test.

摘要

目的

1995年3月20日,日本“奥姆真理教”成员在东京使用沙林毒气,造成12人死亡,5500多名无辜民众受伤。大多数伤亡人员为轻伤。本文回顾了部分受害者在过去十年中的神经学随访数据。

方法

我们查阅了已发表的关于受害者神经学随访的文献,并根据袭击发生后的时间对数据进行了分类。

结果

在一些调查中,数字广度测试、手指敲击测试和计算机化姿势描记法是仅有的在受害者和对照组之间显示出统计学显著差异的性能测试。袭击7年后的主要后遗症是创伤后应激障碍。

结论

结果强调了由国家卫生系统牵头制定针对此类大规模伤亡事件的国家防备计划的必要性。这应包括通过性能测试和创伤后应激障碍筛查测试进行长期的神经学随访监测。

相似文献

1
A decade after the Tokyo sarin attack: a review of neurological follow-up of the victims.东京沙林毒气袭击事件十年后:受害者神经学随访情况综述
Mil Med. 2007 Jun;172(6):607-10. doi: 10.7205/milmed.172.6.607.
2
Insomnia as a sequela of sarin toxicity several years after exposure in Tokyo subway trains.在东京地铁列车接触沙林毒气数年之后,失眠成为沙林中毒的后遗症。
Percept Mot Skills. 2005 Jun;100(3 Pt 2):1121-6. doi: 10.2466/pms.100.3c.1121-1126.
3
The Tokyo subway sarin attack has long-term effects on survivors: A 10-year study started 5 years after the terrorist incident.东京地铁沙林毒气袭击事件对幸存者有长期影响:一项在恐怖事件发生5年后启动的为期10年的研究。
PLoS One. 2020 Jun 23;15(6):e0234967. doi: 10.1371/journal.pone.0234967. eCollection 2020.
4
Psycho-physiological effects of the terrorist sarin attack on the Tokyo subway system.恐怖分子在东京地铁系统发动沙林袭击事件的心理生理影响。
Mil Med. 2001 Dec;166(12 Suppl):23-6.
5
Effects of sarin on the nervous system in rescue team staff members and police officers 3 years after the Tokyo subway sarin attack.东京地铁沙林毒气袭击事件三年后,沙林对救援队工作人员和警察神经系统的影响。
Environ Health Perspect. 2001 Nov;109(11):1169-73. doi: 10.1289/ehp.011091169.
6
Prehospital management of sarin nerve gas terrorism in urban settings: 10 years of progress after the Tokyo subway sarin attack.城市环境中沙林神经毒气恐怖袭击的院前管理:东京地铁沙林袭击事件后的十年进展
Resuscitation. 2006 Feb;68(2):193-202. doi: 10.1016/j.resuscitation.2005.05.023. Epub 2005 Dec 1.
7
Post-traumatic stress disorder symptoms in victims of Tokyo subway attack: a 5-year follow-up study.东京地铁袭击受害者的创伤后应激障碍症状:一项5年随访研究。
Psychiatry Clin Neurosci. 2004 Dec;58(6):624-9. doi: 10.1111/j.1440-1819.2004.01313.x.
8
Case report: Long-term cognitive sequelae of sarin exposure.病例报告:沙林暴露的长期认知后遗症。
Neurotoxicology. 2010 Mar;31(2):244-6. doi: 10.1016/j.neuro.2009.12.004. Epub 2009 Dec 29.
9
Sarin experiences in Japan: acute toxicity and long-term effects.日本的沙林事件:急性毒性和长期影响。
J Neurol Sci. 2006 Nov 1;249(1):76-85. doi: 10.1016/j.jns.2006.06.007. Epub 2006 Sep 7.
10
Support for relationship between serum cholinesterase and post-traumatic stress disorder; 5-year follow-ups of victims of the Tokyo subway sarin poisoning.血清胆碱酯酶与创伤后应激障碍之间关系的支持证据;东京地铁沙林毒气中毒受害者的5年随访
Neurosci Res. 2005 Jun;52(2):129-31. doi: 10.1016/j.neures.2005.03.012.

引用本文的文献

1
Attenuation of Nerve Agent Induced Neurodegenerative and Neuroinflammatory Changes in Rats with New Combination Treatment of Galantamine, Atropine and Midazolam.加兰他敏、阿托品和咪达唑仑联合新疗法减轻大鼠神经毒剂诱导的神经退行性和神经炎症变化
Mol Neurobiol. 2025 Jan;62(1):461-474. doi: 10.1007/s12035-024-04294-2. Epub 2024 Jun 13.
2
Preventing Long-Term Brain Damage by Nerve Agent-Induced Status Epilepticus in Rat Models Applicable to Infants: Significant Neuroprotection by Tezampanel Combined with Caramiphen but Not by Midazolam Treatment.通过适用于婴儿的神经毒剂诱导的癫痫持续状态大鼠模型预防长期脑损伤:替扎尼定联合卡马西平治疗具有显著神经保护作用,而咪达唑仑治疗则无。
J Pharmacol Exp Ther. 2024 Jan 17;388(2):432-450. doi: 10.1124/jpet.123.001710.
3
Mortality and cancer incidence in UK military veterans involved in human experiments at Porton Down: 48-year follow-up.英国参与过波顿唐人体实验的退伍军人的死亡率和癌症发病率:48 年随访研究。
Int J Epidemiol. 2023 Aug 2;52(4):1025-1034. doi: 10.1093/ije/dyad050.
4
Synthesis and preliminary biological evaluation of gabactyzine, a benactyzine-GABA mutual prodrug, as an organophosphate antidote.加巴喷丁-GABA 前药加巴喷嗪的合成及初步生物学评价作为一种有机磷解毒剂。
Sci Rep. 2022 Oct 27;12(1):18078. doi: 10.1038/s41598-022-23141-9.
5
Retrograde activation of CB1R by muscarinic receptors protects against central organophosphorus toxicity.毒蕈碱型乙酰胆碱受体对 CB1R 的逆行激活可预防中枢性有机磷中毒。
Neuropharmacology. 2019 Sep 1;155:113-120. doi: 10.1016/j.neuropharm.2019.05.028. Epub 2019 May 24.
6
Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure.延迟给予咪达唑仑对有机磷暴露啮齿动物模型的抗惊厥和神经保护作用。
Epilepsia. 2019 Jul;60(7):1387-1398. doi: 10.1111/epi.16050. Epub 2019 May 24.
7
Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain.新型苯氧烷基吡啶𬭩肟对大鼠脑内有机磷诱导损伤的神经保护作用。
Toxicol Sci. 2018 Dec 1;166(2):420-427. doi: 10.1093/toxsci/kfy212.
8
The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203.两种新制备的双吡啶肟(K305、K307)对塔崩中毒大鼠的重活化和神经保护作用评估——与双复磷及肟K203的比较
Molecules. 2017 Jul 11;22(7):1152. doi: 10.3390/molecules22071152.
9
Long-term neuropathological and behavioral impairments after exposure to nerve agents.接触神经毒剂后的长期神经病理学和行为损伤。
Ann N Y Acad Sci. 2016 Jun;1374(1):17-28. doi: 10.1111/nyas.13028. Epub 2016 Mar 22.
10
α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology.α-亚麻酸,一种具有多效特性的营养保健品,其靶向内源性神经保护途径以预防有机磷酸酯神经毒剂诱导的神经病理学。
Molecules. 2015 Nov 12;20(11):20355-80. doi: 10.3390/molecules201119698.