Lazo M D, Andrade R, Medina M C, Garcia-Fernandez G, Sanchez-Cantos A M, Franquelo E
Gastrointestinal Unit, University Hospital Virgen de la Victoria, Málaga, Spain.
Am J Gastroenterol. 1992 Jul;87(7):843-6.
To assess the efficacy of injection therapy with alcohol on prevent rebleeding and emergency surgery in patients with gastroduodenal ulcers and nonbleeding visible vessels, we have performed a prospective controlled trial involving 39 patients who were classified into two groups according to the time of the day on which emergency endoscopy was performed: group 1 (25 patients) in which endoscopic hemostasis with absolute alcohol was performed, and group 2 (14 patients) in which conventional therapy was applied (blood transfusions, antacids, and ranitidine). The two groups were comparable with regard to age, sex, and type of bleeding. The rebleeding rate/emergency surgery rate of 8%/4%, respectively, for group 1 was lower than the 57%/50% for group 2 (p less than 0.001). Our results suggest that endoscopic hemostasis with alcohol should be considered as the initial treatment of choice in patients who present with major upper gastrointestinal hemorrhage and are found to have an ulcer with a nonbleeding visible vessel.
为评估酒精注射疗法对预防胃十二指肠溃疡合并无出血可见血管患者再出血及急诊手术的疗效，我们进行了一项前瞻性对照试验，纳入39例患者，根据急诊内镜检查时间分为两组：第1组（25例患者）采用无水酒精内镜止血，第2组（14例患者）采用传统疗法（输血、抗酸剂和雷尼替丁）。两组在年龄、性别和出血类型方面具有可比性。第1组的再出血率/急诊手术率分别为8%/4%，低于第2组的57%/50%（p<0.001）。我们的结果表明，对于出现上消化道大出血且发现有溃疡伴无出血可见血管的患者，酒精内镜止血应被视为首选的初始治疗方法。
