Yang Xing, Wan De-Sen
State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P. R. China.
Ai Zheng. 2005 Sep;24(9):1161-4.
Insulin-like growth factor (IGF) system plays an important role in regulating cell proliferation and differentiation, and inhibiting apoptosis. In the development, maintenance, and progression of tumor, any abnormality in IGF signal pathway can stimulate tumor growth. In vivo and in vitro experiments have confirmed that IGF system takes part in the malignant cell transformation, growth, invasion, and metastasis of tumor. This review summarized the roles of IGF system in colorectal carcinoma, and discussed its application perspective to early screening and target therapy for colorectal carcinoma.
胰岛素样生长因子（IGF）系统在调节细胞增殖与分化以及抑制细胞凋亡方面发挥着重要作用。在肿瘤的发生、维持和进展过程中，IGF信号通路的任何异常都可刺激肿瘤生长。体内和体外实验均证实，IGF系统参与肿瘤的恶性细胞转化、生长、侵袭和转移。本文综述了IGF系统在结直肠癌中的作用，并探讨了其在结直肠癌早期筛查和靶向治疗中的应用前景。
