Botsis Dimitrios, Christodoulakos George, Papagianni Vassiliki, Lambrinoudaki Irini, Aravantinos Leon, Makrakis Evangelos, Creatsas George
2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, 76 Vas. Sofias Av., Athens 11528, Greece.
Maturitas. 2006 Feb 20;53(3):362-8. doi: 10.1016/j.maturitas.2005.06.010. Epub 2005 Sep 12.
To evaluate and compare the effect of different than classical hormone therapy medications, such as raloxifene and tibolone, on the uterine arteries and endometrium of postmenopausal women using transvaginal ultrasonography.
The prospective study included 62 healthy, postmenopausal women recruited from the Menopausal Clinic of the 2nd Department of Obstetrics and Gynecology of the University of Athens. Subjects were randomly allocated to receive raloxifene HCl in a daily dose of 60 mg orally (Group A-31 women) or tibolone in a daily dose of 2.5 mg orally (Group B-31 women). The study period was 6 months and all subjects were assessed using transvaginal ultrasonography before treatment initiation as well as after 3 and 6 months for evaluation of the endometrial thickness and the pulsatility (PI) and resistance (RI) indices at the level of the uterine arteries.
No significant differences in RI, PI and endometrial thickness were observed in the raloxifene group during the 6-month treatment. In the tibolone group, PI and RI values decreased linearly from baseline to the end of the study, whereas the endometrial thickness was significantly increased during the first 3 months remaining unaltered thereafter. Comparisons between the two study groups revealed significant percent change of values in the pre-treatment to month-3 period and no difference with regard to pre-treatment, month-3 and month-6 absolute values.
Raloxifene and tibolone exert dissimilar effects on uterine blood supply parameters and endometrial thickness.
使用经阴道超声评估并比较不同的非传统激素治疗药物，如雷洛昔芬和替勃龙，对绝经后女性子宫动脉和子宫内膜的影响。
这项前瞻性研究纳入了从雅典大学第二妇产科绝经诊所招募的62名健康绝经后女性。受试者被随机分配，分别口服每日剂量60毫克的盐酸雷洛昔芬（A组，31名女性）或每日剂量2.5毫克的替勃龙（B组，31名女性）。研究期为6个月，所有受试者在治疗开始前以及治疗3个月和6个月后均接受经阴道超声检查，以评估子宫内膜厚度以及子宫动脉水平的搏动指数（PI）和阻力指数（RI）。
在6个月的治疗期间，雷洛昔芬组的RI、PI和子宫内膜厚度均未观察到显著差异。在替勃龙组中，PI和RI值从基线到研究结束呈线性下降，而子宫内膜厚度在最初3个月显著增加，此后保持不变。两个研究组之间的比较显示，治疗前至第3个月期间数值的百分比变化显著，而治疗前、第3个月和第6个月的绝对值无差异。
雷洛昔芬和替勃龙对子宫血液供应参数和子宫内膜厚度有不同影响。
