Reid I A
Am J Physiol. 1992 Jun;262(6 Pt 1):E763-78. doi: 10.1152/ajpendo.1992.262.6.E763.
The renin-angiotensin system plays an important role in the regulation of arterial blood pressure and in the development of some forms of clinical and experimental hypertension. It is an important blood pressure control system in its own right but also interacts extensively with other blood pressure control systems, including the sympathetic nervous system and the baroreceptor reflexes. Angiotensin (ANG) II exerts several actions on the sympathetic nervous system. These include a central action to increase sympathetic outflow, stimulatory effects on sympathetic ganglia and the adrenal medulla, and actions at sympathetic nerve endings that serve to facilitate sympathetic neurotransmission. ANG II also interacts with baroreceptor reflexes. For example, it acts centrally to modulate the baroreflex control of heart rate, and this accounts for its ability to increase blood pressure without causing a reflex bradycardia. The physiological significance of these actions of ANG II is not fully understood. Most evidence indicates that the actions of ANG to enhance sympathetic activity do not contribute significantly to the pressor response to exogenous ANG II. On the other hand, there is considerable evidence that the actions of endogenous ANG II on the sympathetic nervous system enhance the cardiovascular responses elicited by activation of the sympathetic nervous system.
肾素 - 血管紧张素系统在动脉血压调节以及某些临床和实验性高血压的发生发展过程中发挥着重要作用。它本身就是一个重要的血压控制系统，但也与其他血压控制系统广泛相互作用，包括交感神经系统和压力感受器反射。血管紧张素（ANG）II对交感神经系统有多种作用。这些作用包括增加交感神经输出的中枢作用、对交感神经节和肾上腺髓质的刺激作用，以及在交感神经末梢促进交感神经传递的作用。ANG II还与压力感受器反射相互作用。例如，它在中枢发挥作用，调节心率的压力反射控制，这就解释了它在不引起反射性心动过缓的情况下升高血压的能力。ANG II这些作用的生理意义尚未完全明确。大多数证据表明，ANG增强交感神经活动的作用对外源性ANG II的升压反应贡献不大。另一方面，有大量证据表明，内源性ANG II对交感神经系统的作用会增强交感神经系统激活所引发的心血管反应。
