Sproul Duncan, Gilbert Nick, Bickmore Wendy A
Chromosomes and Gene Expression Section, Medical Research Council Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom.
Nat Rev Genet. 2005 Oct;6(10):775-81. doi: 10.1038/nrg1688.
Much of what we know about the chromatin-based mechanisms that regulate gene expression in mammals has come from the study of what are, paradoxically, atypical genes. These are clusters of structurally and/or functionally related genes that are coordinately regulated during development, or between different cell types. Can unravelling the mechanisms of gene regulation at these gene clusters help us to understand how other genes are controlled? Moreover, can it explain why there is clustering of apparently unrelated genes in mammalian genomes?
我们对哺乳动物中基于染色质调节基因表达的机制的许多了解，都来自对一类看似非典型基因的研究。这些基因是结构和/或功能相关的基因簇，在发育过程中或不同细胞类型之间受到协同调节。解开这些基因簇的基因调控机制，能否帮助我们理解其他基因是如何被控制的？此外，它能否解释为什么哺乳动物基因组中会存在看似不相关基因的聚类现象？
