拉各斯地区2型糖尿病患者的抗坏血酸和α-生育酚抗氧化状态

Ascorbic Acid and Alpha Tocopherol Antioxidant Status of Type 2 Diabetes Mellitus Patients seen in Lagos.

作者信息

Dogun E S, Ajala M O

机构信息

Department of Chemical Pathology, College of Medicine, Benin, Benin-City.

出版信息

Niger Postgrad Med J. 2005 Sep;12(3):155-7.

PMID:16160714

Abstract

SUMMARY

This study was carried out with the aim of assessing the plasma status of ascorbic acid and alpha-tocopherol in Nigerian type 2 diabetes mellitus patients It was a cross sectional study, made up of 70 type 2 diabetes mellitus patients and 40 healthy controls. The plasma levels of vitamins C and E were measured, so also were the fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1C). Results showed significantly lower plasma levels of vitamin C and vitamin E in the patients, compared with the controls. The correlation studies between vitamins C and E on the one hand, versus (FPG) and HbA1c on the other hand were not contributory.The conclusion from this study, is that, there is a reduction in plasma levels of anti-oxidant vitamins C and E in type 2 DM but this does not have any particular relationship with the levels of FPG or HbA1C.

KEYWORDS

type 2 Dm, ascorbic Acid, alpha tocopherol antioxidant status.

摘要

本研究旨在评估尼日利亚2型糖尿病患者血浆中抗坏血酸和α-生育酚的状况。这是一项横断面研究，由70名2型糖尿病患者和40名健康对照组成。测量了血浆中维生素C和E的水平，同时也测量了空腹血糖（FPG）和糖化血红蛋白（HbA1C）。结果显示，与对照组相比，患者血浆中维生素C和维生素E的水平显著降低。维生素C和E之间以及它们与FPG和HbA1c之间的相关性研究并无贡献。本研究的结论是，2型糖尿病患者血浆中抗氧化维生素C和E的水平降低，但这与FPG或HbA1C的水平没有任何特定关系。