Ripon Monjurul Islam, Prattay Kazi Milenur Rahman, Kumar Uttom, Monjur Al Hossain A S M, Asaduzzaman Muhammad, Redwan Matin Zidan B M, Chandra Das Sreedam
Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh.
School of Pharmacy, BRAC University, Dhaka 1212, Bangladesh.
Glob Health Epidemiol Genom. 2025 Jun 18;2025:9923689. doi: 10.1155/ghe3/9923689. eCollection 2025.
Type 2 diabetes mellitus (T2DM) links to oxidative stress in both its origin and progression. Vitamin E has the potential to be a highly effective therapeutic intervention in fighting against T2DM as it protects cells against oxidative stress. While some interventional studies have explored the effect of vitamin E on T2DM, there is a lack of cross-sectional studies globally, and none to our knowledge on the Bangladeshi population. Consequently, it is worthwhile to investigate the serum vitamin E levels in Bangladeshi T2DM patients. 94 T2DM patients and 30 healthy subjects were evaluated for their serum vitamin E concentration for a comparative cross-sectional study. Mean serum concentrations were compared between these two groups, as well as among different sex and age groups using independent sample -test and one-way ANOVA, as appropriate. The serum vitamin E concentration was significantly lower in T2DM patients (mean ± standard deviation: 8.97 ± 2.99 μg/mL) than in healthy subjects (13.13 ± 2.70 μg/mL), < 0.001. Additionally, male T2DM patients had significantly higher serum vitamin E levels compared to those in female patients (9.73 ± 3.02 μg/mL in males vs. 7.74 ± 2.53 μg/mL in females; =0.001). The study showed a significant fall in serum vitamin E concentration with increasing age in T2DM patients (≤ 30 years: 12.7 ± 1.05 μg/mL vs. 31-50 years: 11.06 ± 2.65 μg/mL vs. 51-70 years: 8 ± 2.04 μg/mL vs. 71-90 years: 6.05 ± 0.78 μg/mL; < 0.001). Our findings suggest that lower serum vitamin E levels are significantly associated with T2DM, particularly among female and older patients, highlighting the potential relevance of antioxidant status in T2DM management.
2型糖尿病（T2DM）在其发病和进展过程中均与氧化应激相关。维生素E有潜力成为对抗T2DM的一种高效治疗干预手段，因为它能保护细胞免受氧化应激的影响。虽然一些干预性研究探讨了维生素E对T2DM的影响，但全球范围内缺乏横断面研究，据我们所知，尚无针对孟加拉人群的此类研究。因此，调查孟加拉T2DM患者的血清维生素E水平是很有必要的。本研究对94例T2DM患者和30名健康受试者的血清维生素E浓度进行了评估，以开展一项比较性横断面研究。使用独立样本t检验和单因素方差分析（适当时）对这两组以及不同性别和年龄组之间的平均血清浓度进行了比较。T2DM患者的血清维生素E浓度（均值±标准差：8.97±2.99μg/mL）显著低于健康受试者（13.13±2.70μg/mL），P＜＜0.001。此外，男性T2DM患者的血清维生素E水平显著高于女性患者（男性为9.73±3.02μg/mL，女性为7.74±2.53μg/mL；P = 0.001）。该研究表明，T2DM患者的血清维生素E浓度随年龄增长而显著下降（≤30岁：12.7±1.05μg/mL，31 - 50岁：11.06±2.65μg/mL，51 - 70岁：8±2.04μg/mL，71 - 90岁：6.05±0.78μg/mL；P＜＜0.001）。我们的研究结果表明，较低血清维生素E水平与T2DM显著相关，尤其是在女性和老年患者中，这凸显了抗氧化状态在T2DM管理中的潜在重要性。
