Rich G F, Schacterle R, Moscicki J C, DiFazio C A, Adams J M
Department of Anesthesiology, University of Virginia Health Sciences Center, Charlottesville 22908.
Anesth Analg. 1992 Jul;75(1):99-102.
To determine the effects of intravenous (IV) ketorolac on anesthesia and the mechanisms involved, we evaluated its effects on minimum alveolar anesthetic concentration (MAC) and ventilation in halothane-anesthetized rats. Ketorolac in clinical (0.2 and 2 mg/kg) and large (20 and 40 mg/kg) IV doses did not affect the MAC of halothane (0.82% +/- 0.02%). Resting end-tidal CO2 tension (5.1% +/- 0.1%) and the slope of the CO2 response curves (70 +/- 6 mL.min-1.%-1) were also unaffected by IV ketorolac. The mean arterial blood pressure did not significantly change after ketorolac in doses of 0.2, 2, or 20 mg/kg but decreased significantly (P less than 0.05) after 40 mg/kg (placebo 99 +/- 8 mm Hg; ketorolac 87 +/- 6 mm Hg). This study demonstrates that MAC, ventilation, and mean arterial blood pressure are unaffected by clinical doses of IV ketorolac. Furthermore, the lack of effect on MAC and ventilation from larger doses suggests that ketorolac does not have mechanisms of action in the central nervous system.
为确定静脉注射酮咯酸对麻醉的影响及其相关机制，我们评估了其对氟烷麻醉大鼠最低肺泡有效浓度（MAC）和通气的影响。临床剂量（0.2和2mg/kg）及大剂量（20和40mg/kg）静脉注射酮咯酸均未影响氟烷的MAC（0.82%±0.02%）。静息呼气末二氧化碳分压（5.1%±0.1%）及二氧化碳反应曲线斜率（70±6mL·min⁻¹·%⁻¹）也不受静脉注射酮咯酸的影响。0.2、2或20mg/kg剂量的酮咯酸注射后平均动脉血压无显著变化，但40mg/kg剂量注射后显著降低（P<0.05）（安慰剂组99±8mmHg；酮咯酸组87±6mmHg）。本研究表明，临床剂量的静脉注射酮咯酸不影响MAC、通气及平均动脉血压。此外，大剂量对MAC和通气无影响提示酮咯酸在中枢神经系统无作用机制。
