新型碳酸氢化林格氏液BRS对失血性休克犬的药理学研究。

Pharmacological study of BRS, a new bicarbonated Ringer's solution, in haemorrhagic shock dogs.

作者信息

Satoh K, Ohtawa M, Katoh M, Okamura E, Satoh T, Matsuura A, Oi Y, Ogawa R

机构信息

Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co Ltd, Shizuoka, Japan.

出版信息

Eur J Anaesthesiol. 2005 Sep;22(9):703-11. doi: 10.1017/s026502150500116x.

DOI:10.1017/s026502150500116x

PMID:16163918

Abstract

BACKGROUND AND OBJECTIVES

Sodium bicarbonate is the most physiological alkalinizing agent. The effect of a new bicarbonated Ringer's solution (BRS) containing Mg2+, on metabolic acidosis and serum magnesium abnormality were evaluated and compared with those of acetated Ringer's (ARS), lactated Ringer's (LRS) and Ringer's (RS) solutions in an experimental haemorrhagic shock model with dogs.

METHODS

Animals were randomly divided into six groups (n = 6 in each group), a sham-operated group, an operated group without infusion, and 4 operated groups with infusion (BRS, ARS, LRS and RS groups). Each RS was intravenously administered at 60 mL kg(-1) h(-1) for 1.5 h. Arterial blood gases, plasma electrolytes and cardiovascular parameters were analysed.

RESULTS

BRS significantly improved blood base excess values, which were decreased by blood-letting, faster and more markedly than did LRS and RS (BRS--6.3 +/- 0.5 mEq L(-1); LRS--9.2 +/- 1.1 mEq L(-1); RS--12.4 +/- 1.0 mEq L(-1) at the end of infusion). The alkalinizing effect of BRS tended to be better than that of ARS but not significantly so. The serum Mg2+ concentration was well-maintained by BRS as compared to other RS (BRS 1.5 +/- 0.0 mgdL(-1); ARS 1.2 +/- 0.0mgdL(-1); LRS 1.1 +/- 0.0mgdL(-1); RS 1.3 +/- 0.1 mgdL(-1), at the end of infusion).

CONCLUSIONS

These results suggest that BRS is a suitable perioperative solution for metabolic acidosis and serum electrolyte balance among RS tested.

摘要

背景与目的

碳酸氢钠是最具生理特性的碱化剂。在犬失血性休克实验模型中，评估了一种含镁的新型碳酸氢林格液（BRS）对代谢性酸中毒和血清镁异常的影响，并与醋酸林格液（ARS）、乳酸林格液（LRS）和林格液（RS）进行比较。

方法

将动物随机分为六组（每组n = 6），即假手术组、未输液的手术组以及4个输液手术组（BRS组、ARS组、LRS组和RS组）。每组均以60 mL·kg⁻¹·h⁻¹的速度静脉输注1.5小时。分析动脉血气、血浆电解质和心血管参数。

结果

BRS显著改善了因放血而降低的血液碱剩余值，其改善速度比LRS和RS更快且更明显（输注结束时，BRS为-6.3±0.5 mEq·L⁻¹；LRS为-9.2±1.1 mEq·L⁻¹；RS为-12.4±1.0 mEq·L⁻¹）。BRS的碱化效果倾向于优于ARS，但差异无统计学意义。与其他溶液相比，BRS能更好地维持血清Mg²⁺浓度（输注结束时，BRS为1.5±0.0 mg·dL⁻¹；ARS为1.2±0.0 mg·dL⁻¹；LRS为1.1±0.0 mg·dL⁻¹；RS为1.3±0.1 mg·dL⁻¹）。