韩国产质粒介导的AmpCβ-内酰胺酶CMY-2的肠炎沙门氏菌分离株的出现情况。

Appearance of Salmonella enterica isolates producing plasmid-mediated AmpC beta-lactamase, CMY-2, in South Korea.

作者信息

Song Wonkeun, Kim Jae-Seok, Kim Han-Sung, Park Min-Jeong, Lee Kyu Man

机构信息

Department of Laboratory Medicine, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, 948-1, Daelim-dong, Youngdeungpo-gu, Seoul 150-950, South Korea.

出版信息

Diagn Microbiol Infect Dis. 2005 Aug;52(4):281-4. doi: 10.1016/j.diagmicrobio.2005.04.010.

DOI:10.1016/j.diagmicrobio.2005.04.010

PMID:16165000

Abstract

Of 176 Salmonella isolates isolated from 2000 to 2003 in a Korean university hospital, 2 cefoxitin-resistant isolates of Salmonella enterica serovar Rissen were found in 2002. Both isolates were resistant to multiple beta-lactam antibiotics, including ampicillin, amoxicillin-clavulanate, cefoxitin, cefotaxime, and ceftazidime. Cell sonicates of the both clinical isolates and their transconjugants had beta-lactamase band of approximate isoelectric point of >8.6. The resistance to cefoxitin was transferred by conjugation to the recipient Escherichia coli J53. The resistance determinant was on conjugative plasmids that encoded a CMY-2, a plasmid-mediated AmpC beta-lactamase. To our knowledge, these are the first description of S. enterica serovar Rissen harboring CMY-2 in South Korea.

摘要

在一所韩国大学医院于2000年至2003年间分离出的176株沙门氏菌中，2002年发现了2株对头孢西丁耐药的肠炎沙门氏菌血清型里森菌株。这两株菌株对多种β-内酰胺类抗生素耐药，包括氨苄西林、阿莫西林-克拉维酸、头孢西丁、头孢噻肟和头孢他啶。这两株临床分离株及其接合子的细胞超声裂解物具有等电点约>8.6的β-内酰胺酶条带。对头孢西丁的耐药性通过接合转移至受体大肠杆菌J53。耐药决定簇位于编码CMY-2（一种质粒介导的AmpCβ-内酰胺酶）的接合质粒上。据我们所知，这些是韩国首次报道的携带CMY-2的肠炎沙门氏菌血清型里森菌株。