Minami Takashi, Aird William C
The Research Center for Advanced Science and Technology, the University of Tokyo, Tokyo 153-8904, Japan.
Trends Cardiovasc Med. 2005 Jul;15(5):174-84. doi: 10.1016/j.tcm.2005.06.002.
Endothelial cells (ECs) display phenotypic heterogeneity. Endothelial cell heterogeneity is mediated, at least in part, by site-specific and time-dependent differences in gene transcription. The goal of this review is to provide a conceptual framework for approaching EC gene regulation in the adult vasculature. We summarize data from cell culture studies that provide insight into the transcription factors involved in mediating gene expression in ECs. Next, we review the results of in vivo studies relating to gene regulation in the intact endothelium. Finally, we draw on both the in vitro and in vivo results to propose a model of gene regulation that emphasizes the importance of the extracellular environment in controlling site- and time-specific vascular gene expression.
内皮细胞（ECs）表现出表型异质性。内皮细胞异质性至少部分地由基因转录中位点特异性和时间依赖性差异介导。本综述的目的是为研究成年脉管系统中内皮细胞基因调控提供一个概念框架。我们总结了细胞培养研究的数据，这些数据有助于深入了解介导内皮细胞基因表达的转录因子。接下来，我们回顾与完整内皮中基因调控相关的体内研究结果。最后，我们借鉴体外和体内研究结果，提出一个基因调控模型，该模型强调细胞外环境在控制位点特异性和时间特异性血管基因表达中的重要性。
