Vespa Laurent, Couvillion Mary, Spangler Elizabeth, Shippen Dorothy E
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA.
Genes Dev. 2005 Sep 15;19(18):2111-5. doi: 10.1101/gad.1333805.
Here we examine the function of ATM and ATR at telomeres in Arabidopsis. Although plants lacking ATM or ATR display wild-type telomere length homeostasis, chromosome end protection is compromised in atm atr mutants. Moreover, atm tert Arabidopsis experience an abrupt, early onset of genome instability, arguing that ATM is required for protection of short telomeres. ATR, by contrast, is required for maintenance of telomeric DNA as telomere shortening is dramatically accelerated in atr tert mutants relative to tert plants. Thus, ATM and ATR make essential and distinct contributions to chromosome end protection and telomere maintenance in higher eukaryotes.
在此，我们研究了拟南芥端粒中ATM和ATR的功能。尽管缺乏ATM或ATR的植物表现出野生型端粒长度稳态，但atm atr突变体中染色体末端保护功能受损。此外，atm tert拟南芥经历了基因组不稳定的突然且早期发作，这表明ATM是保护短端粒所必需的。相比之下，ATR是维持端粒DNA所必需的，因为相对于tert植物，atr tert突变体中端粒缩短显著加速。因此，ATM和ATR对高等真核生物的染色体末端保护和端粒维持做出了重要且不同的贡献。
