Sander Valeria, Solano María Emilia, Elia Evelin, Luchetti Carolina Griselda, Di Girolamo Guillermo, Gonzalez Claudio, Motta Alicia B
Centro de Estudios Farmacológicos y Botánicos, Consejo de Investigaciones Científicas y Tecnológicas, Buenos Aires, Argentina.
Neuroimmunomodulation. 2005;12(5):285-92. doi: 10.1159/000087106.
The aim of the present report was to study the role of high levels of dehydroepiandrosterone (DHEA) on the ovarian function and embryonic resorption during early pregnancy in BALB/c mice. Pregnant animals were injected with DHEA following both the post-implantatory (DHEA-2) and peri-implantatory (DHEA-6) models. Morphological studies of implantation sites showed 40% of embryonic resorption in the DHEA-2 group while 100% of resorption was observed in the DHEA-6 group. Serum samples of both DHEA-2 and DHEA-6 groups showed higher estradiol levels and a lower progesterone concentration than those of control groups. Ovarian prostaglandin E levels after both DHEA-2 and DHEA-6 treatments increased when compared to control groups. The antioxidant metabolite glutathione diminished during both DHEA treatments. In summary, the data presented here suggest that DHEA treatment during early pregnancy modulates the ovarian function and is responsible for embryonic resorption with different degrees depending on when it is administered.
本报告的目的是研究高水平脱氢表雄酮（DHEA）对BALB/c小鼠妊娠早期卵巢功能和胚胎吸收的作用。在植入后（DHEA-2）和植入周围（DHEA-6）模型下，对怀孕动物注射DHEA。对植入部位的形态学研究显示，DHEA-2组有40%的胚胎吸收，而DHEA-6组观察到100%的吸收。DHEA-2组和DHEA-6组的血清样本显示，与对照组相比，雌二醇水平较高，孕酮浓度较低。与对照组相比，DHEA-2和DHEA-6处理后的卵巢前列腺素E水平均升高。在两种DHEA处理过程中，抗氧化代谢物谷胱甘肽减少。总之，此处呈现的数据表明，妊娠早期进行DHEA处理会调节卵巢功能，并根据给药时间的不同导致不同程度的胚胎吸收。
