Ardehali Hossein
Feinberg Cardiovascular Institute, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA.
J Bioenerg Biomembr. 2005 Jun;37(3):171-7. doi: 10.1007/s10863-005-6582-8.
Several ion channels are expressed in the inner and outer membranes of mitochondria, but the exact function of these channels is not completely understood. The opening of certain channels is thought to induce the process of cell death or apoptosis. However, other channels of the inner mitochondrial membrane help protect against ischemic injury and oxidative stress. Mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)) and mitochondrial Ca(2+)-activated K(+) channels (mitoK(Ca)) are the primary protective channels that have been identified. In addition to their thermogenic role, certain isoforms of uncoupling proteins are also shown to have protective roles in certain experimental models. This review attempts to provide an updated overview of the proposed mechanism for the protective function of these membrane proteins. Controversies and unanswered questions regarding these channels will also be discussed.
几种离子通道在线粒体内膜和外膜中表达，但这些通道的确切功能尚未完全明确。某些通道的开放被认为会诱导细胞死亡或凋亡过程。然而，线粒体内膜的其他通道有助于抵御缺血性损伤和氧化应激。线粒体ATP敏感性钾通道（mitoK(ATP)）和线粒体钙激活钾通道（mitoK(Ca)）是已被确定的主要保护通道。除了其产热作用外，解偶联蛋白的某些亚型在某些实验模型中也显示出保护作用。本综述试图对这些膜蛋白保护功能的提出机制提供最新概述。还将讨论关于这些通道的争议和未解决的问题。
