[中国遗传性非息肉病性结直肠癌的临床病理特征分析]
[Analysis of the clinicopathological features of Chinese hereditary nonpolyposis colorectal cancer].
作者信息
Jin Hei-ying, Cui Long, Ding Yi-jiang, Yan Yu-ti, Meng Rong-gui, Liu Fei, Zhang Xiao-chun, Yu De-hong
机构信息
National Center of Colorectal Surgery, The Third Affiliated Hospital, Nanjing University of TCM, Nanjing 210001, China.
出版信息
Zhonghua Wei Chang Wai Ke Za Zhi. 2005 Jul;8(4):316-8.
OBJECTIVE
To investigate the clinicopathological features of Chinese hereditary nonpolyposis colorectal cancer (HNPCC).
METHODS
Patients who met the Amsterdam criteria were enrolled in this study from several hospitals in China. Clinicopathological features of patients with HNPCC were compared between the patients with suspected HNPCC and sporadic colorectal cancer.
RESULTS
One hundred and sixty-seven individuals from 31 families met the Amsterdam criteria. The average age was 48.6 (22-78) years old. There were 43 cases (31.9%) with ascending colon cancer and 52 cases (38.5%) with rectal cancer. The 3-, 5-, 10- years survival rate was 70.3%, 49.9% and 39.7% respectively. The incidence of multiple primary neoplasms was 20.4% .
CONCLUSIONS
Chinese HNPCC is characterized by early disease onset. Rectal cancer and ascending colon cancer are the first and the secondly common cancer for Chinese HNPCC. Gastric cancer is the most common parenteral cancer in Chinese HNPCC families.
目的
探讨中国遗传性非息肉病性结直肠癌（HNPCC）的临床病理特征。
方法
从中国多家医院招募符合阿姆斯特丹标准的患者。比较疑似HNPCC患者和散发性结直肠癌患者的HNPCC临床病理特征。
结果
来自31个家庭的167人符合阿姆斯特丹标准。平均年龄为48.6（22 - 78）岁。升结肠癌43例（31.9%），直肠癌52例（38.5%）。3年、5年、10年生存率分别为70.3%、49.9%和39.7%。多原发性肿瘤的发生率为20.4%。
结论
中国HNPCC的特点是发病年龄早。直肠癌和升结肠癌是中国HNPCC最常见和次常见的癌症。胃癌是中国HNPCC家族中最常见的肠外癌症。
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