Carraway Kermit L, Ramsauer Victoria P, Carraway Coralie A Carothers
Department of Cell Biology and Anatomy, University of Miami School of Medicine, Miami, Florida 33101, USA.
J Cell Biochem. 2005 Dec 1;96(5):914-26. doi: 10.1002/jcb.20612.
Mammary function is dependent on its three-dimensional organization, which is established and maintained by cell adhesive junctions linked through the membrane to the cell cytoskeleton. These junctions serve not only as structural elements, but also function as initiators and integrators of cell signals. In this review we discuss three types of glycoproteins whose interactions impinge on the function of mammary cell-cell junctions, cadherins, ErbB receptor tyrosine kinases and membrane mucins, as a microcosm of events regulating mammary cell behaviors. Actions of these components are integrated by the critical signaling element beta-catenin. When functioning properly, these glycoproteins, beta-catenin and associated signaling pathways mesh into a highly structured program for development and function of the gland. However, disruption or dysfunction of these glycoproteins or the signaling elements can lead to disorganization of the epithelia and ultimately to neoplasia.
乳腺功能依赖于其三维组织结构，这种结构由通过膜与细胞细胞骨架相连的细胞黏附连接建立并维持。这些连接不仅作为结构元件，还作为细胞信号的启动器和整合器。在本综述中，我们讨论三种糖蛋白，其相互作用影响乳腺细胞间连接的功能，即钙黏蛋白、表皮生长因子受体酪氨酸激酶和膜黏蛋白，作为调节乳腺细胞行为事件的一个缩影。这些成分的作用由关键信号元件β-连环蛋白整合。当正常发挥功能时，这些糖蛋白、β-连环蛋白和相关信号通路融入一个高度结构化的程序，以实现腺体的发育和功能。然而，这些糖蛋白或信号元件的破坏或功能障碍可导致上皮组织紊乱，最终导致肿瘤形成。
