Sandoval Rodríguez Ana Soledad, Salazar Montes Adriana María, Armendáriz-Borunda Juan
Instituto de Biología Molecular en Medicina y Terapia Génica. CUCS. Universidad de Guadalajara CA-77.
Rev Gastroenterol Mex. 2005 Apr-Jun;70(2):192-202.
Gene therapy has evolved due to the development of a number of biotechnology weapons, i.e., vectors that achieve for a longer expression and safer administration. Among viral vectors developed adeno-associated virus have shown promising advantages. These DNA viruses transduce a wide cell range, can integrate in host's genome and achieve for a long-period expression, besides avoiding a cellular immune response. The new technologies applied to the production and purification of these vectors had resulted in notable increases in quantity and quality of the infectious particles obtained. Actually, due to biotechnological advances, gene therapy is a potential therapeutic option.
