Klabatsa A, Sheaff M T, Steele J P C, Evans M T, Rudd R M, Fennell D A
Bart's Mesothelioma Research, Institute of Pathology, Royal London Hospital, Queen Mary School of Medicine and Dentistry, London E1 1BB, UK.
Lung Cancer. 2006 Jan;51(1):53-9. doi: 10.1016/j.lungcan.2005.07.010. Epub 2005 Sep 16.
Malignant pleural mesothelioma (MPM) is a highly chemoresistant cancer with a poor prognosis. Hypoxia is a specific property of solid tumours, contributes to low apoptotic potential, and can be selectively targeted by bioreductive drugs. Hypoxia-inducible factor 1alpha (HIF-1alpha) is a subunit of a heterodimeric transcription complex that regulates several genes associated with tumour progression and anti-apoptosis. In this study, we measured for the first time the expression of HIF-1alpha in MPM. Our results show that HIF-1alpha is commonly expressed in MPM but not in normal mesothelium, consistent with the presence of hypoxia. HIF-1alpha does not appear to predict survival; however, this study suggests that bioreductive drugs should be investigated in clinical trials of MPM.
恶性胸膜间皮瘤（MPM）是一种化疗耐药性高、预后差的癌症。缺氧是实体瘤的一个特殊特性，它导致低凋亡潜能，并且可被生物还原药物选择性靶向。缺氧诱导因子1α（HIF-1α）是一种异二聚体转录复合物的亚基，该复合物调节与肿瘤进展和抗凋亡相关的多个基因。在本研究中，我们首次测量了MPM中HIF-1α的表达。我们的结果表明，HIF-1α在MPM中普遍表达，但在正常间皮中不表达，这与缺氧的存在一致。HIF-1α似乎不能预测生存率；然而，本研究表明应在MPM的临床试验中研究生物还原药物。
