血浆氧化型低密度脂蛋白循环水平与冠状动脉支架置入术后临床结局之间缺乏关联。

Lack of association between circulating levels of plasma oxidized low-density lipoproteins and clinical outcome after coronary stenting.

作者信息

Braun Siegmund, Ndrepepa Gjin, von Beckerath Nicolas, Mehilli Julinda, Gorchakova Olga, Vogt Wolfgang, Schömig Albert, Kastrati Adnan

机构信息

Institut für Laboratoriumsmedizin, Technische Universität München, Munich, Germany.

出版信息

Am Heart J. 2005 Sep;150(3):550-6. doi: 10.1016/j.ahj.2004.10.008.

DOI:10.1016/j.ahj.2004.10.008

PMID:16169339

Abstract

BACKGROUND

We undertook this study to investigate whether there is an association between circulating oxidized low-density lipoproteins (OxLDLs) and outcome after coronary stenting.

METHODS

The study included 687 patients with coronary artery disease who underwent coronary stenting. Oxidized low-density lipoproteins were measured before coronary angiography. The median of OxLDL concentrations was 67.7 U/L. Patients were divided into 2 groups: the group with OxLDL levels < median (low OxLDL group, n = 345) and the group with OxLDL levels > or = median (high OxLDL group, n = 342). The combined incidence of major adverse cardiac events (death, myocardial infarction, and target vessel revascularization) was the primary end point. Angiographic restenosis was also evaluated.

RESULTS

The combined incidence of death, myocardial infarction, and target vessel revascularization was 27.2% (n = 94) in the low OxLDL group and 25.4% (n = 87) in the high OxLDL group (OR .92, 95% CI 0.68-1.23, P = .59). At 6-month angiography, restenosis was found in 28.1% of the patients (n = 74) in the low OxLDL group and in 24.2% of the patients (n = 61) in the high OxLDL group. (P = .31).

CONCLUSION

Our study shows no association between circulating levels of OxLDL and restenosis or other adverse events in patients with coronary artery disease after coronary stenting.

摘要

背景

我们开展这项研究以调查循环氧化低密度脂蛋白（OxLDLs）与冠状动脉支架置入术后的预后之间是否存在关联。

方法

该研究纳入了687例行冠状动脉支架置入术的冠心病患者。在冠状动脉造影术前测定氧化低密度脂蛋白水平。OxLDL浓度的中位数为67.7 U/L。患者被分为两组：OxLDL水平<中位数的组（低OxLDL组，n = 345）和OxLDL水平≥中位数的组（高OxLDL组，n = 342）。主要不良心脏事件（死亡、心肌梗死和靶血管血运重建）的联合发生率是主要终点。还评估了血管造影再狭窄情况。

结果

低OxLDL组死亡、心肌梗死和靶血管血运重建的联合发生率为27.2%（n = 94），高OxLDL组为25.4%（n = 87）（OR 0.92，95% CI 0.68 - 1.23，P = 0.59）。在6个月时的血管造影检查中，低OxLDL组28.1%的患者（n = 74）发现有再狭窄，高OxLDL组24.2%的患者（n = 61）发现有再狭窄（P = 0.31）。