Sumner Michael D, Elliott-Eller Melanie, Weidner Gerdi, Daubenmier Jennifer J, Chew Mailine H, Marlin Ruth, Raisin Caren J, Ornish Dean
The Preventive Medicine Research Institute, Sausalito, California, USA.
Am J Cardiol. 2005 Sep 15;96(6):810-4. doi: 10.1016/j.amjcard.2005.05.026.
Pomegranate juice contains antioxidants such as soluble polyphenols, tannins, and anthocyanins and may have antiatherosclerotic properties. However, no study has investigated the effects of pomegranate juice on patients who have ischemic coronary heart disease (CHD). We investigated whether daily consumption of pomegranate juice for 3 months would affect myocardial perfusion in 45 patients who had CHD and myocardial ischemia in a randomized, placebo-controlled, double-blind study. Patients were randomly assigned into 1 of 2 groups: a pomegranate juice group (240 ml/day) or a placebo group that drank a beverage of similar caloric content, amount, flavor, and color. Participants underwent electrocardiographic-gated myocardial perfusion single-photon emission computed tomographic technetium-99m tetrofosmin scintigraphy at rest and during stress at baseline and 3 months. Visual scoring of images using standardized segmentation and nomenclature (17 segments, scale 0 to 4) was performed by a blinded independent nuclear cardiologist. To assess the amount of inducible ischemia, the summed difference score (SDS) was calculated by subtracting the summed score at rest from the summed stress score. The experimental and control groups showed similar levels of stress-induced ischemia (SDS) at baseline (p >0.05). After 3 months, the extent of stress-induced ischemia decreased in the pomegranate group (SDS -0.8 +/- 2.7) but increased in the control group (SDS 1.2 +/- 3.1, p <0.05). This benefit was observed without changes in cardiac medications, blood sugar, hemoglobin A1c, weight, or blood pressure in either group. In conclusion, daily consumption of pomegranate juice may improve stress-induced myocardial ischemia in patients who have CHD.
石榴汁含有可溶性多酚、单宁和花青素等抗氧化剂，可能具有抗动脉粥样硬化特性。然而，尚无研究调查石榴汁对缺血性冠心病（CHD）患者的影响。在一项随机、安慰剂对照、双盲研究中，我们调查了45例患有CHD和心肌缺血的患者每日饮用石榴汁3个月是否会影响心肌灌注。患者被随机分为两组中的一组：石榴汁组（240毫升/天）或饮用热量、量、味道和颜色相似饮料的安慰剂组。参与者在基线和3个月时于静息和负荷状态下接受心电图门控心肌灌注单光子发射计算机断层扫描锝-99m替曲膦闪烁显像。由一位盲法独立核心脏病专家使用标准化分割和命名法（17节段，0至4级）对图像进行视觉评分。为评估诱导性缺血的程度，通过将负荷状态下的总分减去静息状态下的总分来计算总差异评分（SDS）。实验组和对照组在基线时应激诱导缺血（SDS）水平相似（p>0.05）。3个月后，石榴汁组应激诱导缺血程度降低（SDS -0.8±2.7），而对照组升高（SDS 1.2±3.1，p<0.05）。在两组中均未观察到心脏药物、血糖、糖化血红蛋白、体重或血压发生变化的情况下出现了这种益处。总之，每日饮用石榴汁可能改善CHD患者应激诱导的心肌缺血。
