Portig Irene, Sandmöller Andrea, Pankuweit Sabine, Maisch Bernhard
Klinik für Innere Medizin-Kardiologie, Angiologie und Prävention, Philipps-Universität Marburg, Baldingerstrasse, 35033, Marburg.
Herz. 2005 Sep;30(6):522-6. doi: 10.1007/s00059-005-2713-6.
Women's greater susceptibility to autoimmune diseases has been recognized for more than 100 years. And although the basic immune response (including a more vigorous immune response and increased antibody production) has been known to differ between men and women, conclusive pathophysiological explanations for this phenomenon are still lacking. Experimental work done in animal models have revealed a profound influence of sex hormones on the susceptibility to autoimmune diseases and on clinical disease via direct and indirect signaling pathways. Apart from sex hormones additional factors seem to participate in the pathogenesis of autoimmune diseases, which remain to be elucidated ("so far, you cannot explain autoimmunity [only] with estrogen" [lockshin]).
100多年来，人们已经认识到女性更容易患自身免疫性疾病。尽管已知男性和女性的基本免疫反应（包括更强有力的免疫反应和抗体产生增加）有所不同，但对于这一现象仍缺乏确凿的病理生理学解释。在动物模型中进行的实验工作表明，性激素通过直接和间接信号通路对自身免疫性疾病的易感性和临床疾病有深远影响。除了性激素外，似乎还有其他因素参与自身免疫性疾病的发病机制，这些因素仍有待阐明（“到目前为止，你不能[仅]用雌激素来解释自身免疫性疾病”[洛克申]）。
