苯并[d]异硒唑-3-酮与空间位阻脂环胺及氮氧化物的结合：作为谷胱甘肽过氧化物酶模拟物的活性增强
Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics.
作者信息
Kálai Tamas, Mugesh Govindasamy, Roy Gouriprasanna, Sies Helmut, Berente Zoltán, Hideg Kálmán
机构信息
Institute of Organic and Medicinal Chemistry, University of Pécs, P. O. Box 99, H-7602, Pécs, Hungary.
出版信息
Org Biomol Chem. 2005 Oct 7;3(19):3564-9. doi: 10.1039/b509865c. Epub 2005 Aug 31.
DOI:10.1039/b509865c
PMID:16172695
Abstract
Benzo[d]isoselenazol-3-ones N-substituted with sterically hindered diamagnetic and paramagnetic five- or six-membered nitroxides or their precursors, including ring-opened diselenides, exhibit synergism in glutathione peroxidase (GPx) activity.
摘要
被空间位阻的抗磁性和顺磁性五元或六元氮氧化物或其前体（包括开环二硒化物）N-取代的苯并[d]异硒唑-3-酮在谷胱甘肽过氧化物酶（GPx）活性方面表现出协同作用。
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